diff --git a/code/modules/organs/organ.dm b/code/modules/organs/organ.dm
index 0f576de6c04..26e6c71f51b 100644
--- a/code/modules/organs/organ.dm
+++ b/code/modules/organs/organ.dm
@@ -326,11 +326,11 @@
 		if(antibiotics >= 5)
 			germ_level = 0 //just finish up this small infection
 		else
-			germ_level -= antibiotics * 5 //Clears very quickly, finishing up remnants of infection
+			germ_level = max(germ_level - (antibiotics * 5), 0) //Clears very quickly, finishing up remnants of infection
 	else if(germ_level <= INFECTION_LEVEL_TWO)
-		germ_level -= min(antibiotics, 6) //Still quick, infection's not too bad. At max dose and germ_level 500, should take a minute or two
+		germ_level = max(germ_level - min(antibiotics, 6), 0) //Still quick, infection's not too bad. At max dose and germ_level 500, should take a minute or two
 	else
-		germ_level -= min(antibiotics * 0.5, 3) //Big infections, very slow to stop. At max dose and germ_level 1000, should take five to six minutes
+		germ_level = max(germ_level - min(antibiotics * 0.5, 3), 0) //Big infections, very slow to stop. At max dose and germ_level 1000, should take five to six minutes
 
 //Adds autopsy data for used_weapon.
 /obj/item/organ/proc/add_autopsy_data(var/used_weapon, var/damage)
diff --git a/html/changelogs/doxxmedearly - negative_infections.yml b/html/changelogs/doxxmedearly - negative_infections.yml
new file mode 100644
index 00000000000..1c6d09ae84a
--- /dev/null
+++ b/html/changelogs/doxxmedearly - negative_infections.yml	
@@ -0,0 +1,6 @@
+author: Doxxmedearly
+
+delete-after: True
+
+changes:
+  - bugfix: "Fixed an issue with the germ counter going into negative values on limbs, which caused odd behavior such as reoccurring infections."