diff --git a/code/modules/mob/living/basic/farm_animals/bee/_bee.dm b/code/modules/mob/living/basic/farm_animals/bee/_bee.dm
index a175deacb93..655d08aa864 100644
--- a/code/modules/mob/living/basic/farm_animals/bee/_bee.dm
+++ b/code/modules/mob/living/basic/farm_animals/bee/_bee.dm
@@ -258,6 +258,9 @@
 	var/datum/reagent/chemical = needle.reagents.get_master_reagent()
 	if(isnull(chemical))
 		return
+	if(!(chemical.chemical_flags & REAGENT_CAN_BE_SYNTHESIZED))
+		to_chat(user, span_warning("[chemical.name] cannot be inserted into a bee's genome!"))
+		return
 	if(chemical.type == queen.beegent?.type)
 		to_chat(user, span_warning("[queen] already has this chemical!"))
 		return