diff --git a/code/_globalvars/configuration.dm b/code/_globalvars/configuration.dm
index e43d803fc4f..5bece07319c 100644
--- a/code/_globalvars/configuration.dm
+++ b/code/_globalvars/configuration.dm
@@ -11,10 +11,6 @@ GLOBAL_VAR_INIT(hub_visibility, FALSE)
 
 GLOBAL_VAR_INIT(ooc_allowed, TRUE) // used with admin verbs to disable ooc - not a config option apparently
 GLOBAL_VAR_INIT(dooc_allowed, TRUE)
-GLOBAL_VAR_INIT(enter_allowed, TRUE)
-GLOBAL_VAR_INIT(shuttle_frozen, FALSE)
-GLOBAL_VAR_INIT(shuttle_left, FALSE)
-GLOBAL_VAR_INIT(tinted_weldhelh, TRUE)
 
 
 // Debug is used exactly once (in living.dm) but is commented out in a lot of places.  It is not set anywhere and only checked.
diff --git a/code/_globalvars/game_modes.dm b/code/_globalvars/game_modes.dm
index 8a1493e383d..10d92334371 100644
--- a/code/_globalvars/game_modes.dm
+++ b/code/_globalvars/game_modes.dm
@@ -1,8 +1,6 @@
 GLOBAL_VAR(common_report) //Contains common part of roundend report
 GLOBAL_VAR(survivor_report) //Contains shared survivor report for roundend report (part of personal report)
 
-
-GLOBAL_VAR_INIT(wavesecret, 0) // meteor mode, delays wave progression, terrible name
 GLOBAL_DATUM(start_state, /datum/station_state) // Used in round-end report
 
 /// We want reality_smash_tracker to exist only once and be accessible from anywhere.
diff --git a/code/_globalvars/lists/mapping.dm b/code/_globalvars/lists/mapping.dm
index 45f59fb4475..a7c7584d23a 100644
--- a/code/_globalvars/lists/mapping.dm
+++ b/code/_globalvars/lists/mapping.dm
@@ -132,9 +132,6 @@ GLOBAL_LIST_EMPTY(bar_areas)
 /// List of all the maps that have been cached for /proc/load_map
 GLOBAL_LIST_EMPTY(cached_maps)
 
-/// Away missions
-GLOBAL_LIST_EMPTY(vr_spawnpoints)
-
 /// Just a list of all the area objects in the game
 /// Note, areas can have duplicate types
 GLOBAL_LIST_EMPTY(areas)
diff --git a/code/_globalvars/lists/mobs.dm b/code/_globalvars/lists/mobs.dm
index 942c8cbf6b1..d91eec6e1bc 100644
--- a/code/_globalvars/lists/mobs.dm
+++ b/code/_globalvars/lists/mobs.dm
@@ -43,7 +43,6 @@ GLOBAL_LIST_INIT(abstract_mob_types, list(
 GLOBAL_LIST_EMPTY(player_list) //all mobs **with clients attached**.
 GLOBAL_LIST_EMPTY(keyloop_list) //as above but can be limited to boost performance
 GLOBAL_LIST_EMPTY(mob_list) //all mobs, including clientless
-GLOBAL_LIST_EMPTY(mob_directory) //mob_id -> mob
 GLOBAL_LIST_EMPTY(alive_mob_list) //all alive mobs, including clientless. Excludes /mob/dead/new_player
 GLOBAL_LIST_EMPTY(suicided_mob_list) //contains a list of all mobs that suicided, including their associated ghosts.
 GLOBAL_LIST_EMPTY(drones_list)
@@ -56,7 +55,6 @@ GLOBAL_LIST_EMPTY(mob_living_list) //all instances of /mob/living and subtypes
 GLOBAL_LIST_EMPTY(carbon_list) //all instances of /mob/living/carbon and subtypes, notably does not contain brains or simple animals
 GLOBAL_LIST_EMPTY(human_list) //all instances of /mob/living/carbon/human and subtypes
 GLOBAL_LIST_EMPTY(ai_list)
-GLOBAL_LIST_EMPTY(pai_list)
 GLOBAL_LIST_EMPTY(available_ai_shells)
 GLOBAL_LIST_INIT(simple_animals, list(list(),list(),list())) // One for each AI_* status define
 GLOBAL_LIST_EMPTY(spidermobs) //all sentient spider mobs
@@ -133,8 +131,6 @@ GLOBAL_LIST_INIT_TYPED(species_prototypes, /datum/species, init_species_prototyp
 		species_list[species_type] = new species_type()
 	return species_list
 
-GLOBAL_LIST_EMPTY(sentient_disease_instances)
-
 GLOBAL_LIST_EMPTY(latejoin_ai_cores)
 
 GLOBAL_LIST_EMPTY(mob_config_movespeed_type_lookup)
diff --git a/code/modules/mob/mob.dm b/code/modules/mob/mob.dm
index e692ee49403..aaacfcd6a27 100644
--- a/code/modules/mob/mob.dm
+++ b/code/modules/mob/mob.dm
@@ -6,7 +6,6 @@
  * * GLOB.dead_mob_list
  * * GLOB.alive_mob_list
  * * GLOB.all_clockwork_mobs
- * * GLOB.mob_directory
  *
  * Unsets the focus var
  *
@@ -67,7 +66,6 @@
  *
  * Adds to global lists
  * * GLOB.mob_list
- * * GLOB.mob_directory (by tag)
  * * GLOB.dead_mob_list - if mob is dead
  * * GLOB.alive_mob_list - if the mob is alive
  *
diff --git a/code/modules/mob/mob_lists.dm b/code/modules/mob/mob_lists.dm
index 9fd097a1fd6..f43f82ac246 100644
--- a/code/modules/mob/mob_lists.dm
+++ b/code/modules/mob/mob_lists.dm
@@ -1,12 +1,10 @@
 ///Adds the mob reference to the list and directory of all mobs. Called on Initialize().
 /mob/proc/add_to_mob_list()
 	GLOB.mob_list |= src
-	GLOB.mob_directory[tag] = src
 
 ///Removes the mob reference from the list and directory of all mobs. Called on Destroy().
 /mob/proc/remove_from_mob_list()
 	GLOB.mob_list -= src
-	GLOB.mob_directory -= tag
 
 ///Adds the mob reference to the list of all mobs alive. If mob is cliented, it adds it to the list of all living player-mobs.
 /mob/proc/add_to_alive_mob_list()
diff --git a/code/modules/pai/pai.dm b/code/modules/pai/pai.dm
index 5e8636460d8..6f19dc7d7ca 100644
--- a/code/modules/pai/pai.dm
+++ b/code/modules/pai/pai.dm
@@ -164,7 +164,6 @@
 	QDEL_NULL(signaler)
 	QDEL_NULL(leash)
 	card = null
-	GLOB.pai_list.Remove(src)
 	return ..()
 
 /mob/living/silicon/pai/emag_act(mob/user)
@@ -213,7 +212,6 @@
 	if(istype(loc, /obj/item/modular_computer))
 		give_messenger_ability()
 	START_PROCESSING(SSfastprocess, src)
-	GLOB.pai_list += src
 	make_laws()
 	for(var/law in laws.inherent)
 		lawcheck += law