diff --git a/code/_globalvars/lists/reagents.dm b/code/_globalvars/lists/reagents.dm
index 225b12c8353..8aeacb6f583 100644
--- a/code/_globalvars/lists/reagents.dm
+++ b/code/_globalvars/lists/reagents.dm
@@ -58,6 +58,8 @@ GLOBAL_LIST_INIT(blacklisted_metalgen_types, typecacheof(list(
 GLOBAL_LIST_INIT(name2reagent, build_name2reagentlist())
 /// list of all plan traits
 GLOBAL_LIST_INIT(plant_traits, init_plant_traits())
+/// List of all reagent side effects
+GLOBAL_LIST_INIT(stacked_metabolization_effect, init_chemical_side_effects())
 
 /// Initialises all /datum/reagent into a list indexed by reagent id
 /proc/init_chemical_reagent_list()
@@ -198,3 +200,9 @@ GLOBAL_LIST_INIT(plant_traits, init_plant_traits())
 	//build map with sorted keys
 	for(var/name in only_names)
 		.[name] = name_to_reagent[name]
+
+/proc/init_chemical_side_effects()
+	. = list()
+
+	for(var/datum/stacked_metabolization_effect/effect as anything in valid_subtypesof(/datum/stacked_metabolization_effect))
+		. += new effect()
diff --git a/code/modules/reagents/chemistry/holder/mob_life.dm b/code/modules/reagents/chemistry/holder/mob_life.dm
index 978f1fb0d99..693dc8bb885 100644
--- a/code/modules/reagents/chemistry/holder/mob_life.dm
+++ b/code/modules/reagents/chemistry/holder/mob_life.dm
@@ -30,6 +30,7 @@
 		liver_tolerance = liver.toxTolerance * liver_health_percent
 		provide_pain_message = HAS_NO_TOXIN
 
+	var/list/reagents_metabolized = list()
 	for(var/datum/reagent/reagent as anything in cached_reagents)
 		var/datum/reagent/toxin/toxin
 		if(istype(reagent, /datum/reagent/toxin))
@@ -44,7 +45,7 @@
 				owner.reagents.remove_reagent(toxin.type, toxin.metabolization_rate * owner.metabolism_efficiency * seconds_per_tick)
 				continue
 
-		need_mob_update += metabolize_reagent(owner, reagent, seconds_per_tick, can_overdose, liverless, dead)
+		need_mob_update += metabolize_reagent(owner, reagent, seconds_per_tick, can_overdose, liverless, dead, reagents_metabolized)
 
 		// If applicable, calculate any toxin-related liver damage
 		// Note: we have to do this AFTER metabolize_reagent, because we want handle_reagent to run before we make the determination.
@@ -66,8 +67,15 @@
 	if(provide_pain_message && liver.damage > 10 && SPT_PROB(liver.damage/6, seconds_per_tick)) //the higher the damage the higher the probability
 		to_chat(owner, span_warning("You feel a dull pain in your abdomen."))
 
-	if(owner && need_mob_update) //some of the metabolized reagents had effects on the mob that requires some updates.
-		owner.updatehealth()
+	if(owner)
+		//apply side effects based on reagents metabolized
+		if(reagents_metabolized.len > 1)
+			for(var/datum/stacked_metabolization_effect/effect as anything in GLOB.stacked_metabolization_effect)
+				need_mob_update += effect.check_and_apply(reagents_metabolized, owner, seconds_per_tick)
+
+		//some of the metabolized reagents had effects on the mob that requires some updates.
+		if(need_mob_update)
+			owner.updatehealth()
 
 #undef HAS_SILENT_TOXIN
 #undef HAS_NO_TOXIN
@@ -80,11 +88,11 @@
  * Arguments:
  * * mob/living/carbon/owner - The mob to metabolize in, if null it uses [/datum/reagents/var/my_atom]
  * * seconds_per_tick - the time in server seconds between proc calls (when performing normally it will be 2)
- * * times_fired - the number of times the owner's life() tick has been called aka The number of times SSmobs has fired
  * * can_overdose - Allows overdosing
  * * liverless - Stops reagents that aren't set as [/datum/reagent/var/self_consuming] from metabolizing
+ * * list/reagents_metabolized - a list to hold the reagent metabolized with the metabolization ratio
  */
-/datum/reagents/proc/metabolize_reagent(mob/living/carbon/owner, datum/reagent/reagent, seconds_per_tick, can_overdose = FALSE, liverless = FALSE, dead = FALSE)
+/datum/reagents/proc/metabolize_reagent(mob/living/carbon/owner, datum/reagent/reagent, seconds_per_tick, can_overdose = FALSE, liverless = FALSE, dead = FALSE, list/reagents_metabolized)
 	if(QDELETED(reagent.holder))
 		return FALSE
 
@@ -104,6 +112,8 @@
 	var/need_mob_update = FALSE
 	var/metabolized_volume = reagent.compute_metabolization(owner, seconds_per_tick)
 	var/metabolization_ratio = REM * metabolized_volume
+	if(reagents_metabolized)
+		reagents_metabolized[reagent.type] = metabolization_ratio
 	if(can_overdose && !HAS_TRAIT(owner, TRAIT_OVERDOSEIMMUNE))
 		if(reagent.overdose_threshold && reagent.volume >= reagent.overdose_threshold && !reagent.overdosed)
 			reagent.overdosed = TRUE
diff --git a/code/modules/reagents/stacked_effects/stacked_effects.dm b/code/modules/reagents/stacked_effects/stacked_effects.dm
new file mode 100644
index 00000000000..c1e76e1857d
--- /dev/null
+++ b/code/modules/reagents/stacked_effects/stacked_effects.dm
@@ -0,0 +1,61 @@
+///Side effects from metabolizing an reagent or a combination of them
+/datum/stacked_metabolization_effect
+	abstract_type = /datum/stacked_metabolization_effect
+	///List of reagents that need to be metabolized for this side effect to kick in. For subtypes values greater than requirement list will also trigger this effect
+	var/list/datum/reagent/requirements
+
+/**
+ * Returns the average metabolzation ratio from an list
+ * Arguments
+ *
+ * * list/reagents_metabolized - the list of reagents metabolized
+*/
+/datum/stacked_metabolization_effect/proc/average(list/reagents_metabolized)
+	SHOULD_BE_PURE(TRUE)
+	SHOULD_NOT_OVERRIDE(TRUE)
+
+	var/average = 0
+	for(var/datum/reagent/test as anything in reagents_metabolized)
+		average += reagents_metabolized[test]
+	return average / reagents_metabolized.len
+
+/**
+ * Checks if this side effect can be applied on the mob
+ * Arguments
+ *
+ * * list/reagents_metabolized - a map of reagent type path -> metabolization_ratio of all reagents
+ * * mob/living/carbon/owner - the mob to apply the side effects to
+ * * seconds_per_tick - passed from /datum/reagents/proc/metabolize_reagent()
+*/
+/datum/stacked_metabolization_effect/proc/check_and_apply(list/reagents_metabolized, mob/living/carbon/owner, seconds_per_tick)
+	SHOULD_NOT_OVERRIDE(TRUE)
+	. = 0
+
+	var/list/datum/reagent/requirements_needed = requirements
+	for(var/datum/reagent/test as anything in reagents_metabolized)
+		for(var/datum/reagent/requirement as anything in requirements_needed)
+			if(ispath(test, requirement))
+				if(requirements_needed == requirements)
+					requirements_needed = requirements.Copy()
+				requirements_needed[requirement] -= 1
+				if(!requirements_needed[requirement])
+					requirements_needed -= requirement
+				break
+
+	if(!requirements_needed.len)
+		return apply(reagents_metabolized, owner, seconds_per_tick)
+
+/**
+ * Apply a list of side effects to an mob once they have metabolized the requirments
+ * Arguments
+ *
+ * * list/reagents_metabolized - a map of reagent -> metabolization_ratio of all reagents
+ * * mob/living/carbon/owner - the mob to apply the side effects to
+ * * seconds_per_tick - passed from /datum/reagents/proc/metabolize_reagent()
+ * Returns a positive value if the mobs health needs to be updated
+*/
+/datum/stacked_metabolization_effect/proc/apply(list/reagents_metabolized, mob/living/carbon/owner, seconds_per_tick)
+	PROTECTED_PROC(TRUE)
+	SHOULD_NOT_SLEEP(TRUE)
+
+	return 0
diff --git a/code/modules/unit_tests/_unit_tests.dm b/code/modules/unit_tests/_unit_tests.dm
index b37ce733209..5894dc7feec 100644
--- a/code/modules/unit_tests/_unit_tests.dm
+++ b/code/modules/unit_tests/_unit_tests.dm
@@ -313,6 +313,7 @@
 #include "spraycan.dm"
 #include "spritesheets.dm"
 #include "stack_singular_name.dm"
+#include "stacked_metab.dm"
 #include "station_trait_tests.dm"
 #include "status_effect_validity.dm"
 #include "stomach.dm"
diff --git a/code/modules/unit_tests/stacked_metab.dm b/code/modules/unit_tests/stacked_metab.dm
new file mode 100644
index 00000000000..94158acb8f5
--- /dev/null
+++ b/code/modules/unit_tests/stacked_metab.dm
@@ -0,0 +1,22 @@
+/datum/unit_test/stacked_metabolization_effect_verify
+
+/datum/unit_test/stacked_metabolization_effect_verify/Run()
+	for(var/datum/stacked_metabolization_effect/effect as anything in valid_subtypesof(/datum/stacked_metabolization_effect))
+		effect = new effect()
+
+		if(!length(effect.requirements))
+			TEST_FAIL("Effect [effect] does not have any requirments!")
+			qdel(effect)
+			continue
+
+		for(var/datum/reagent/key as anything in effect.requirements)
+			if(!ispath(key, /datum/reagent))
+				TEST_FAIL("Effect [effect] has an non reagent key [key] as requirment")
+				break
+
+			var/count = effect.requirements[key]
+			if(count < 1)
+				TEST_FAIL("Effect [effect] has an invalid requirement count [count] for key [key] ")
+				break
+
+		qdel(effect)
diff --git a/tgstation.dme b/tgstation.dme
index 303cf1ab8ce..492cfa5ca93 100644
--- a/tgstation.dme
+++ b/tgstation.dme
@@ -6127,6 +6127,7 @@
 #include "code\modules\reagents\reagent_containers\cups\mauna_mug.dm"
 #include "code\modules\reagents\reagent_containers\cups\organ_jar.dm"
 #include "code\modules\reagents\reagent_containers\cups\soda.dm"
+#include "code\modules\reagents\stacked_effects\stacked_effects.dm"
 #include "code\modules\reagents\withdrawal\_addiction.dm"
 #include "code\modules\reagents\withdrawal\generic_addictions.dm"
 #include "code\modules\recycling\conveyor.dm"