diff --git a/code/modules/reagents/chemistry/reagents/blob_reagents.dm b/code/modules/reagents/chemistry/reagents/blob_reagents.dm
index 51b50bb9397..7db4cb3c752 100644
--- a/code/modules/reagents/chemistry/reagents/blob_reagents.dm
+++ b/code/modules/reagents/chemistry/reagents/blob_reagents.dm
@@ -11,6 +11,7 @@
 	var/blobbernaut_message = "slams" //blobbernaut attack verb
 	var/message = "The blob strikes you" //message sent to any mob hit by the blob
 	var/message_living = null //extension to first mob sent to only living mobs i.e. silicons have no skin to be burnt
+	can_synth = 0
 
 /datum/reagent/blob/proc/send_message(mob/living/M)
 	var/totalmessage = message
diff --git a/code/modules/reagents/chemistry/reagents/medicine_reagents.dm b/code/modules/reagents/chemistry/reagents/medicine_reagents.dm
index df4a732fd52..b81330a3099 100644
--- a/code/modules/reagents/chemistry/reagents/medicine_reagents.dm
+++ b/code/modules/reagents/chemistry/reagents/medicine_reagents.dm
@@ -31,6 +31,7 @@
 	id = "adminordrazine"
 	description = "It's magic. We don't have to explain it."
 	color = "#C8A5DC" // rgb: 200, 165, 220
+	can_synth = 0
 
 /datum/reagent/medicine/adminordrazine/on_mob_life(mob/living/carbon/M)
 	M.reagents.remove_all_type(/datum/reagent/toxin, 5*REM, 0, 1)
diff --git a/code/modules/reagents/chemistry/reagents/other_reagents.dm b/code/modules/reagents/chemistry/reagents/other_reagents.dm
index e022fbda573..64de2aef123 100644
--- a/code/modules/reagents/chemistry/reagents/other_reagents.dm
+++ b/code/modules/reagents/chemistry/reagents/other_reagents.dm
@@ -422,6 +422,7 @@
 	id = "gluttonytoxin"
 	description = "An advanced corruptive toxin produced by something terrible."
 	color = "#5EFF3B" //RGB: 94, 255, 59
+	can_synth = 0
 
 /datum/reagent/gluttonytoxin/reaction_mob(mob/M, method=TOUCH, reac_volume)
 	M.ForceContractDisease(new /datum/disease/transformation/morph(0))
@@ -807,6 +808,7 @@
 	id = "nanomachines"
 	description = "Microscopic construction robots."
 	color = "#535E66" // rgb: 83, 94, 102
+	can_synth = 0
 
 /datum/reagent/nanites/reaction_mob(mob/M, method=TOUCH, reac_volume, show_message = 1, touch_protection = 0)
 	if(method==PATCH || method==INGEST || method==INJECT || (method == VAPOR && prob(min(reac_volume,100)*(1 - touch_protection))))
@@ -817,6 +819,7 @@
 	id = "xenomicrobes"
 	description = "Microbes with an entirely alien cellular structure."
 	color = "#535E66" // rgb: 83, 94, 102
+	can_synth = 0
 
 /datum/reagent/xenomicrobes/reaction_mob(mob/M, method=TOUCH, reac_volume, show_message = 1, touch_protection = 0)
 	if(method==PATCH || method==INGEST || method==INJECT || (method == VAPOR && prob(min(reac_volume,100)*(1 - touch_protection))))
@@ -1238,6 +1241,7 @@ datum/reagent/romerol
 		of the host body."
 	color = "#123524" // RGB (18, 53, 36)
 	metabolization_rate = INFINITY
+	can_synth = 0
 
 /datum/reagent/romerol/on_mob_life(mob/living/carbon/human/H)
 	// Silently add the zombie infection organ to be activated upon death