diff --git a/code/modules/reagents/chemistry/reagents/medicine_reagents.dm b/code/modules/reagents/chemistry/reagents/medicine_reagents.dm
index 0f8f7b35177..89e74b81a32 100644
--- a/code/modules/reagents/chemistry/reagents/medicine_reagents.dm
+++ b/code/modules/reagents/chemistry/reagents/medicine_reagents.dm
@@ -154,9 +154,11 @@
 /datum/reagent/medicine/cryoxadone/on_mob_life(mob/living/carbon/affected_mob, seconds_per_tick, metabolization_ratio)
 	. = ..()
 	metabolization_rate = REAGENTS_METABOLISM * (0.00001 * (affected_mob.bodytemperature ** 2) + 0.5)
-	if(affected_mob.bodytemperature >= T0C || !HAS_TRAIT(affected_mob, TRAIT_KNOCKEDOUT))
+	if(affected_mob.bodytemperature >= T0C)
 		return
 	var/power = -0.00003 * (affected_mob.bodytemperature ** 2) + 3
+	if(HAS_TRAIT(affected_mob, TRAIT_KNOCKEDOUT)) //Significantly more effective when unconscious
+		power *= 2
 	var/need_mob_update
 	need_mob_update = affected_mob.adjust_oxy_loss(-1.5 * power * metabolization_ratio * seconds_per_tick, updating_health = FALSE, required_biotype = affected_biotype, required_respiration_type = affected_respiration_type)
 	need_mob_update += affected_mob.adjust_brute_loss(-0.5 * power * metabolization_ratio * seconds_per_tick, updating_health = FALSE, required_bodytype = affected_bodytype)