diff --git a/code/modules/organs/organ_external.dm b/code/modules/organs/organ_external.dm
index 0db5b9a489..b71d12f5df 100644
--- a/code/modules/organs/organ_external.dm
+++ b/code/modules/organs/organ_external.dm
@@ -320,7 +320,8 @@
 
 		// Internal wounds get worse over time. Low temperatures (cryo) stop them.
 		if(W.internal && !W.is_treated() && owner.bodytemperature >= 170)
-			W.open_wound(0.1 * wound_update_accuracy)
+			if(!owner.reagents.has_reagent("bicaridine"))	//bicard stops internal wounds from growing bigger with time
+				W.open_wound(0.1 * wound_update_accuracy)
 			owner.vessel.remove_reagent("blood",0.07 * W.damage * wound_update_accuracy)
 			if(prob(1 * wound_update_accuracy))
 				owner.custom_pain("You feel a stabbing pain in your [display_name]!",1)
diff --git a/code/modules/organs/organ_internal.dm b/code/modules/organs/organ_internal.dm
index 431804dd98..232fa2bc0e 100644
--- a/code/modules/organs/organ_internal.dm
+++ b/code/modules/organs/organ_internal.dm
@@ -27,11 +27,12 @@
 	H.internal_organs[src.name] = src
 	src.owner = H
 
-/datum/organ/internal/proc/take_damage(amount)
+/datum/organ/internal/proc/take_damage(amount, var/silent=0)
 	src.damage += amount
 
 	var/datum/organ/external/parent = owner.get_organ(parent_organ)
-	owner.custom_pain("Something inside your [parent.display_name] hurts a lot.", 1)
+	if (!silent)
+		owner.custom_pain("Something inside your [parent.display_name] hurts a lot.", 1)
 
 /****************************************************
 				INTERNAL ORGANS DEFINES
@@ -62,6 +63,21 @@
 
 	process()
 		if(owner.life_tick % process_accuracy == 0)
+			//High toxins levels are dangerous
+			if(owner.getToxLoss() >= 60 && !owner.reagents.has_reagent("anti_toxin"))
+				//Healthy liver suffers on its own
+				if (src.damage < min_broken_damage)
+					src.damage += 0.2 * process_accuracy
+				//Damaged one shares the fun
+				else
+					var/victim = pick(owner.internal_organs)
+					var/datum/organ/internal/O = owner.internal_organs[victim]
+					O.damage += 0.2  * process_accuracy
+
+			//Detox can heal small amounts of damage
+			if (owner.reagents.has_reagent("anti_toxin") && src.damage < src.min_bruised_damage)
+				src.damage -= 0.2 * process_accuracy
+
 			// Damaged liver means some chemicals are very dangerous
 			if(src.damage >= src.min_bruised_damage)
 				for(var/datum/reagent/R in owner.reagents.reagent_list)
diff --git a/code/modules/organs/pain.dm b/code/modules/organs/pain.dm
index 7919381c0f..d894d0f081 100644
--- a/code/modules/organs/pain.dm
+++ b/code/modules/organs/pain.dm
@@ -9,6 +9,12 @@ mob/var/next_pain_time = 0
 // amount is a num from 1 to 100
 mob/proc/pain(var/partname, var/amount, var/force, var/burning = 0)
 	if(stat >= 2) return
+	if(reagents.has_reagent("tramadol"))
+		return
+	if(reagents.has_reagent("oxycodone"))
+		return
+	if(analgesic)
+		return
 	if(world.time < next_pain_time && !force)
 		return
 	if(amount > 10 && istype(src,/mob/living/carbon/human))
diff --git a/code/modules/reagents/Chemistry-Reagents.dm b/code/modules/reagents/Chemistry-Reagents.dm
index 2a8f6db50d..39252aa970 100644
--- a/code/modules/reagents/Chemistry-Reagents.dm
+++ b/code/modules/reagents/Chemistry-Reagents.dm
@@ -2807,6 +2807,12 @@ datum
 				if(d >= pass_out)
 					M:paralysis = max(M:paralysis, 20)
 					M:drowsyness  = max(M:drowsyness, 30)
+					if(ishuman(M))
+						var/mob/living/cabon.huan/H = M
+						var/datum/organ/internal/liver/L = H.internal_organs["liver"]
+						if (istype(L))
+							L.take_damage(0.1, 1)
+						H.adjustToxLoss(0.1)
 
 				holder.remove_reagent(src.id, 0.4)
 				..()