diff --git a/code/__HELPERS/lists.dm b/code/__HELPERS/lists.dm
index 827a6348c26..501a6d8c473 100644
--- a/code/__HELPERS/lists.dm
+++ b/code/__HELPERS/lists.dm
@@ -304,4 +304,9 @@ proc/listclearnulls(list/list)
 			if(bitfield & bit)
 				r += bit
 
-	return r
\ No newline at end of file
+	return r
+
+/proc/safe_pick_list(var/list/L)
+	if(L.len)
+		return pick(L)
+	return null
\ No newline at end of file
diff --git a/code/datums/disease.dm b/code/datums/disease.dm
index d273f272a49..deb0f80c9fb 100644
--- a/code/datums/disease.dm
+++ b/code/datums/disease.dm
@@ -17,7 +17,7 @@ to null does not delete the object itself. Thank you.
 
 */
 
-var/list/diseases = typesof(/datum/disease, /datum/disease/advance) - /datum/disease - /datum/disease/advance
+var/list/diseases = typesof(/datum/disease) - /datum/disease
 
 
 /datum/disease
diff --git a/code/datums/diseases/advance/advance.dm b/code/datums/diseases/advance/advance.dm
index f01eacf9f79..53a7ee1588f 100644
--- a/code/datums/diseases/advance/advance.dm
+++ b/code/datums/diseases/advance/advance.dm
@@ -24,11 +24,10 @@ var/list/archive_diseases = list()
 	form = "Advance Disease" // Will let med-scanners know that this disease was engineered.
 	agent = "advance microbes"
 	max_stages = 5
-
+	spread = "Unknown"
 
 	// NEW VARS
 
-	var/alpha_level = 0 // To determine if the advanced disease will overwrite another advance disease.
 	var/list/symptoms = list() // The symptoms of the disease.
 
 /*
@@ -37,7 +36,7 @@ var/list/archive_diseases = list()
 
  */
 
-/datum/disease/advance/New(var/process = 1, var/datum/disease/advance/D)
+/datum/disease/advance/New(var/process = 1, var/datum/disease/advance/D, var/copy = 0)
 
 	// Setup our dictionary if it hasn't already.
 	if(!dictionary_symptoms.len)
@@ -53,7 +52,8 @@ var/list/archive_diseases = list()
 			symptoms = GenerateSymptoms()
 		else
 			symptoms = D.symptoms
-	Refresh() // Refresh our properties and cure.
+			name = D.name
+	Refresh(!copy)
 	..(process, D)
 	return
 
@@ -98,6 +98,12 @@ var/list/archive_diseases = list()
 		for(var/datum/symptom/S in possible_symptoms)
 			AddSymptom(new S.type)
 
+/datum/disease/advance/proc/HasSymptom(var/datum/symptom/S)
+	for(var/datum/symptom/symp in symptoms)
+		if(symp.id == S.id)
+			return 1
+	return 0
+
 // Will generate new unique symptoms, use this if there are none. Returns a list of symptoms that were generated.
 /datum/disease/advance/proc/GenerateSymptoms(var/type_level_limit = RANDOM_STARTING_LEVEL, var/amount_get = 0)
 
@@ -107,28 +113,34 @@ var/list/archive_diseases = list()
 	var/list/possible_symptoms = list()
 	for(var/symp in list_symptoms)
 		var/datum/symptom/S = new symp
-		if((S.level <= type_level_limit) && !(S in symptoms))
-			possible_symptoms += S
+		if(S.level <= type_level_limit)
+			if(!HasSymptom(S))
+				possible_symptoms += S
+
+	if(!possible_symptoms.len)
+		return
+		//error("Advance Disease - We weren't able to get any possible symptoms in GenerateSymptoms([type_level_limit], [amount_get])")
 
 	// Random chance to get more than one symptom
 	var/number_of = amount_get
 	if(!amount_get)
 		number_of = 1
-		while(prob(10))
+		while(prob(20))
 			number_of += 1
 
-	for(var/i = 0; number_of >= i; i++)
+	for(var/i = 1; number_of >= i; i++)
 		var/datum/symptom/S = pick(possible_symptoms)
 		generated += S
 		possible_symptoms -= S
 
 	return generated
 
-/datum/disease/advance/proc/Refresh()
+/datum/disease/advance/proc/Refresh(var/save = 1)
 	//world << "[src.name] \ref[src] - REFRESH!"
 	var/list/properties = GenerateProperties()
 	AssignProperties(properties)
-	archive_diseases[GetDiseaseID()] = src
+	if(save)
+		archive_diseases[GetDiseaseID()] = new /datum/disease/advance(0, src, 1)
 
 //Generate disease properties based on the effects. Returns an associated list.
 /datum/disease/advance/proc/GenerateProperties()
@@ -137,7 +149,7 @@ var/list/archive_diseases = list()
 		CRASH("We did not have any symptoms before generating properties.")
 		return
 
-	var/list/properties = list("resistance" = 0, "stealth" = 0, "stage_rate" = 0, "tansmittable" = 0, "severity" = 0)
+	var/list/properties = list("resistance" = 1, "stealth" = 1, "stage_rate" = 1, "tansmittable" = 1, "severity" = 1)
 
 	for(var/datum/symptom/S in symptoms)
 
@@ -156,30 +168,32 @@ var/list/archive_diseases = list()
 
 		hidden = list( (properties["stealth"] > 2), (properties["stealth"] > 3) )
 		// The more symptoms we have, the less transmittable it is but some symptoms can make up for it.
-		SetSpread(max(BLOOD, min(properties["tansmittable"] - symptoms.len, AIRBORNE)))
+		SetSpread(max(BLOOD, min(round(properties["tansmittable"] - (symptoms.len / 2)), AIRBORNE)))
 		permeability_mod = 0.5 * properties["transmittable"]
 		stage_prob = max(properties["stage_rate"], 1)
 		SetSeverity(properties["severity"])
 		GenerateCure(properties)
+	else
+		CRASH("Our properties were empty or null!")
 
 
 // Assign the spread type and give it the correct description.
 /datum/disease/advance/proc/SetSpread(var/spread_id)
-	//world << "Setting spread type to [spread_id]"
 	switch(spread_id)
 
 		if(NON_CONTAGIOUS)
-			spread = "None"
+			src.spread = "None"
 		if(SPECIAL)
-			spread = "None"
+			src.spread = "None"
 		if(CONTACT_GENERAL, CONTACT_HANDS, CONTACT_FEET)
-			spread = "On contact"
+			src.spread = "On contact"
 		if(AIRBORNE)
-			spread = "Airborne"
+			src.spread = "Airborne"
 		if(BLOOD)
-			spread = "Blood"
+			src.spread = "Blood"
 
 	spread_type = spread_id
+	//world << "Setting spread type to [spread_id]/[spread]"
 
 /datum/disease/advance/proc/SetSeverity(var/level_sev)
 
@@ -204,9 +218,9 @@ var/list/archive_diseases = list()
 // Will generate a random cure, the less resistance the symptoms have, the harder the cure.
 /datum/disease/advance/proc/GenerateCure(var/list/properties = list())
 	if(properties && properties.len)
-		var/res = max(properties["resistance"] - symptoms.len, 0)
+		var/res = max(properties["resistance"] - (symptoms.len / 2), 0)
 		//world << "Res = [res]"
-		switch(res)
+		switch(round(res))
 			// Due to complications, I cannot randomly generate cures or randomly give cures.
 			if(0)
 				cure_id = "nutriment"
@@ -244,8 +258,10 @@ var/list/archive_diseases = list()
 
 // Randomly generate a symptom, has a chance to lose or gain a symptom.
 /datum/disease/advance/proc/Evolve(var/level = 2)
-	AddSymptom(pick(GenerateSymptoms(level, 1)))
-	Refresh()
+	var/s = safe_pick_list(GenerateSymptoms(level, 1))
+	if(s)
+		AddSymptom(s)
+		Refresh()
 	return
 
 // Name the disease.
@@ -253,6 +269,7 @@ var/list/archive_diseases = list()
 	src.name = name
 	return
 
+// Return a unique ID of the disease.
 /datum/disease/advance/proc/GetDiseaseID()
 	var/list/L = list()
 	for(var/datum/symptom/S in symptoms)
@@ -264,9 +281,8 @@ var/list/archive_diseases = list()
 // we take a random symptom away and add the new one.
 /datum/disease/advance/proc/AddSymptom(var/datum/symptom/S)
 
-	for(var/datum/symptom/symp in symptoms)
-		if(S.id == symp.id)
-			return
+	if(HasSymptom(S))
+		return
 
 	if(symptoms.len < 4 + rand(-1, 1))
 		symptoms += S
@@ -275,7 +291,7 @@ var/list/archive_diseases = list()
 		symptoms += S
 	return
 
-// Simply removes the symptom at the moment.
+// Simply removes the symptom and refreshes.
 /datum/disease/advance/proc/RemoveSymptom(var/datum/symptom/S)
 	symptoms -= S
 	return
diff --git a/code/datums/diseases/advance/symptoms/fever.dm b/code/datums/diseases/advance/symptoms/fever.dm
new file mode 100644
index 00000000000..9cd9585eabf
--- /dev/null
+++ b/code/datums/diseases/advance/symptoms/fever.dm
@@ -0,0 +1,32 @@
+/*
+//////////////////////////////////////
+
+Fever
+
+	No change to hidden.
+	Increases resistance.
+	Increases stage speed.
+	Low level.
+
+Bonus
+	Heats up your body.
+
+//////////////////////////////////////
+*/
+
+/datum/symptom/fever
+
+	name = "Fever"
+	stealth = 0
+	resistance = 3
+	stage_speed = 3
+	level = 2
+
+/datum/symptom/fever/Activate(var/datum/disease/advance/A)
+	..()
+	if(prob(SYMPTOM_ACTIVATION_PROB))
+		var/mob/living/carbon/M = A.affected_mob
+		M << "<span class='notice'>[pick("You feel hot.", "You feel like you're burning.")]</span>"
+		M.bodytemperature += 30 * A.stage
+
+	return
diff --git a/code/datums/diseases/advance/symptoms/headache.dm b/code/datums/diseases/advance/symptoms/headache.dm
index 86dd12ad5d1..bb6708b2957 100644
--- a/code/datums/diseases/advance/symptoms/headache.dm
+++ b/code/datums/diseases/advance/symptoms/headache.dm
@@ -5,7 +5,7 @@ Headache
 
 	Noticable.
 	Highly resistant.
-	Doesn't increase stage speed..
+	Increases stage speed..
 	Low Level.
 
 BONUS
@@ -20,7 +20,7 @@ BONUS
 	name = "Headache"
 	stealth = -1
 	resistance = 4
-	stage_speed = 0
+	stage_speed = 2
 	level = 1
 
 /datum/symptom/cough/Activate(var/datum/disease/advance/A)
diff --git a/code/datums/diseases/advance/symptoms/itching.dm b/code/datums/diseases/advance/symptoms/itching.dm
new file mode 100644
index 00000000000..90bfbeba63a
--- /dev/null
+++ b/code/datums/diseases/advance/symptoms/itching.dm
@@ -0,0 +1,31 @@
+/*
+//////////////////////////////////////
+
+Itching
+
+	Not noticable or unnoticable.
+	Resistant.
+	Increases stage speed..
+	Low Level.
+
+BONUS
+	Displays an annoying message!
+	Should be used for buffing your disease.
+
+//////////////////////////////////////
+*/
+
+/datum/symptom/itching
+
+	name = "Itching"
+	stealth = 0
+	resistance = 3
+	stage_speed = 3
+	level = 1
+
+/datum/symptom/itching/Activate(var/datum/disease/advance/A)
+	..()
+	if(prob(SYMPTOM_ACTIVATION_PROB))
+		var/mob/living/M = A.affected_mob
+		M << "<span class='notice'>Your [pick("back", "arm", "leg", "elbow", "head")] itches.</span>"
+	return
\ No newline at end of file
diff --git a/code/datums/diseases/advance/symptoms/sneeze.dm b/code/datums/diseases/advance/symptoms/sneeze.dm
index 5bd7413da4f..a47e0a8b91c 100644
--- a/code/datums/diseases/advance/symptoms/sneeze.dm
+++ b/code/datums/diseases/advance/symptoms/sneeze.dm
@@ -4,7 +4,7 @@
 Sneezing
 
 	Very Noticable.
-	Decreases resistance.
+	Increases resistance.
 	Doesn't increase stage speed.
 	Low Level.
 
@@ -19,17 +19,17 @@ Bonus
 
 	name = "Sneezing"
 	stealth = -2
-	resistance = -1
+	resistance = 2
 	stage_speed = 0
 	level = 1
 
 /datum/symptom/sneeze/Activate(var/datum/disease/advance/A)
 	..()
-	if(prob(SYMPTOM_ACTIVATION_PROB + (A.stage * 2)))
+	if(prob(SYMPTOM_ACTIVATION_PROB))
 		var/mob/living/M = A.affected_mob
 		switch(A.stage)
-			if(1, 2, 3, 4)
-				M.emote("sniffs")
+			if(1, 2, 3)
+				M.visible_message("<B>[M]</B> sniffs.")
 			else
 				M.emote("sneeze")
 				A.spread(A.holder, 5, AIRBORNE)
diff --git a/code/datums/diseases/advance/symptoms/vomit.dm b/code/datums/diseases/advance/symptoms/vomit.dm
index 5acbfde1998..099478a80e2 100644
--- a/code/datums/diseases/advance/symptoms/vomit.dm
+++ b/code/datums/diseases/advance/symptoms/vomit.dm
@@ -41,7 +41,7 @@ Bonus
 /datum/symptom/vomit/proc/Vomit(var/mob/living/M)
 
 	M.Stun(5)
-	M.emote("vomits on the floor")
+	M.visible_message("<B>[M]</B> vomits on the floor!")
 
 	M.nutrition -= 20
 	M.adjustToxLoss(-3)
@@ -79,7 +79,7 @@ Bonus
 /datum/symptom/vomit/blood/Vomit(var/mob/living/M)
 
 	M.Stun(5)
-	M.emote("vomits on the floor")
+	M.visible_message("<B>[M]</B> vomits on the floor!")
 
 	// They lose blood and health.
 	var/brute_dam = M.getBruteLoss()
diff --git a/code/modules/reagents/Chemistry-Machinery.dm b/code/modules/reagents/Chemistry-Machinery.dm
index aafa471762e..23ad3db0826 100644
--- a/code/modules/reagents/Chemistry-Machinery.dm
+++ b/code/modules/reagents/Chemistry-Machinery.dm
@@ -503,7 +503,8 @@
 					D = archive_diseases[path]
 					vaccine_type = path
 				else
-					D = new vaccine_type(0, null)
+					if(vaccine_type in diseases)
+						D = new vaccine_type(0, null)
 
 				if(D)
 					B.name = "[D.name] vaccine bottle"
@@ -531,9 +532,11 @@
 			var/datum/disease/D = null
 			if(!type)
 				var/datum/disease/advance/A = archive_diseases[href_list["create_virus_culture"]]
-				D = new A.type(0, A)
+				if(A)
+					D = new A.type(0, A)
 			else
-				D = new type(0, null)
+				if(type in diseases) // Make sure this is a disease
+					D = new type(0, null)
 			var/list/data = list("viruses"=list(D))
 			var/name = sanitize(input(usr,"Name:","Name the culture",D.name))
 			if(!name || name == " ") name = D.name
@@ -597,6 +600,8 @@
 			dat += "The beaker is empty<BR>"
 		else if(!Blood)
 			dat += "No blood sample found in beaker"
+		else if(!Blood.data)
+			dat += "No blood data found in beaker."
 		else
 			dat += "<h3>Blood sample data:</h3>"
 			dat += "<b>Blood DNA:</b> [(Blood.data["blood_DNA"]||"none")]<BR>"
@@ -617,6 +622,9 @@
 								D = archive_diseases[A.GetDiseaseID()]
 								disease_creation = A.GetDiseaseID()
 
+							if(!D)
+								CRASH("We weren't able to get the advance disease from the archive.")
+
 							dat += "<b>Disease Agent:</b> [D?"[D.agent] - <A href='?src=\ref[src];create_virus_culture=[disease_creation]'>Create virus culture bottle</A>":"none"]<BR>"
 							dat += "<b>Common name:</b> [(D.name||"none")]<BR>"
 							dat += "<b>Description: </b> [(D.desc||"none")]<BR>"
@@ -658,6 +666,7 @@
 	onclose(user, "pandemic")
 	return
 
+
 /obj/machinery/computer/pandemic/attackby(var/obj/I as obj, var/mob/user as mob)
 	if(istype(I, /obj/item/weapon/screwdriver))
 		playsound(src.loc, 'sound/items/Screwdriver.ogg', 50, 1)
diff --git a/code/modules/reagents/Chemistry-Recipes.dm b/code/modules/reagents/Chemistry-Recipes.dm
index efd0e0e69e8..49da2c1ee7c 100644
--- a/code/modules/reagents/Chemistry-Recipes.dm
+++ b/code/modules/reagents/Chemistry-Recipes.dm
@@ -459,8 +459,8 @@ datum
 			name = "Mix Virus"
 			id = "mixvirus"
 			result = "blood"
-			required_reagents = list("blood" = 5, "virusfood" = 5)
-			result_amount = 5
+			required_reagents = list("blood" = 1, "virusfood" = 5)
+			result_amount = 1
 			var/level = 2
 
 			on_reaction(var/datum/reagents/holder, var/created_volume)