diff --git a/code/_globalvars/lists/reagents.dm b/code/_globalvars/lists/reagents.dm
index 30809943a8a..daa2d634b9f 100644
--- a/code/_globalvars/lists/reagents.dm
+++ b/code/_globalvars/lists/reagents.dm
@@ -1,9 +1,9 @@
 // Base chemicals
-var/list/base_chemicals = list("water","oxygen","nitrogen","hydrogen","potassium","mercury","carbon",
+GLOBAL_LIST_INIT(base_chemicals, list("water","oxygen","nitrogen","hydrogen","potassium","mercury","carbon",
 							"chlorine","fluorine","phosphorus","lithium","sulfur","sacid","radium",
-							"iron","aluminum","silicon","sugar","ethanol")
+							"iron","aluminum","silicon","sugar","ethanol"))
 // Standard chemicals
-var/list/standard_chemicals = list("slimejelly","blood","water","lube","charcoal","toxin","cyanide",
+GLOBAL_LIST_INIT(standard_chemicals, list("slimejelly","blood","water","lube","charcoal","toxin","cyanide",
 								"morphine","epinephrine","space_drugs","serotrotium","oxygen","copper",
 								"nitrogen","hydrogen","potassium","mercury","sulfur","carbon","chlorine",
 								"fluorine","sodium","phosphorus","lithium","sugar","sacid","facid",
@@ -15,21 +15,21 @@ var/list/standard_chemicals = list("slimejelly","blood","water","lube","charcoal
 								"cryoxadone","spaceacillin","carpotoxin","lsd","fluorosurfactant",
 								"fluorosurfactant","ethanol","ammonia","diethylamine","antihol","pancuronium",
 								"lipolicide","condensedcapsaicin","frostoil","amanitin","psilocybin",
-								"enzyme","nothing","salglu_solution","antifreeze","neurotoxin")
+								"enzyme","nothing","salglu_solution","antifreeze","neurotoxin"))
 // Rare chemicals
-var/list/rare_chemicals = list("minttoxin","syndicate_nanites", "xenomicrobes")
+GLOBAL_LIST_INIT(rare_chemicals, list("minttoxin","syndicate_nanites", "xenomicrobes"))
 // Standard medicines
-var/list/standard_medicines = list("charcoal","toxin","cyanide","morphine","epinephrine","space_drugs",
+GLOBAL_LIST_INIT(standard_medicines, list("charcoal","toxin","cyanide","morphine","epinephrine","space_drugs",
 								"serotrotium","mutadone","mutagen","teporone","lexorin","silver_sulfadiazine",
 								"salbutamol","perfluorodecalin","omnizine","synaptizine","haloperidol",
 								"potass_iodide","pen_acid","mannitol","oculine","styptic_powder",
 								"methamphetamine","spaceacillin","carpotoxin","lsd","ethanol","ammonia",
 								"diethylamine","antihol","pancuronium","lipolicide","condensedcapsaicin",
-								"frostoil","amanitin","psilocybin","nothing","salglu_solution","neurotoxin")
+								"frostoil","amanitin","psilocybin","nothing","salglu_solution","neurotoxin"))
 // Rare medicines
-var/list/rare_medicines = list("syndicate_nanites","minttoxin","blood", "xenomicrobes")
+GLOBAL_LIST_INIT(rare_medicines, list("syndicate_nanites","minttoxin","blood", "xenomicrobes"))
 // Drinks
-var/list/drinks = list("beer2","hot_coco","orangejuice","tomatojuice","limejuice","carrotjuice",
+GLOBAL_LIST_INIT(drinks, list("beer2","hot_coco","orangejuice","tomatojuice","limejuice","carrotjuice",
 					"berryjuice","poisonberryjuice","watermelonjuice","lemonjuice","banana",
 					"nothing","potato","milk","soymilk","cream","coffee","tea","icecoffee",
 					"icetea","cola","nuka_cola","spacemountainwind","thirteenloko","dr_gibb",
@@ -44,10 +44,13 @@ var/list/drinks = list("beer2","hot_coco","orangejuice","tomatojuice","limejuice
 					"vodkatonic","ginfizz","bahama_mama","singulo","sbiten","devilskiss","red_mead",
 					"mead","iced_beer","grog","aloe","andalusia","alliescocktail","soy_latte",
 					"cafe_latte","acidspit","amasec","neurotoxin","hippiesdelight","bananahonk",
-					"silencer","changelingsting","irishcarbomb","syndicatebomb","erikasurprise","driestmartini", "flamingmoe")
+					"silencer","changelingsting","irishcarbomb","syndicatebomb","erikasurprise","driestmartini", "flamingmoe"))
+
+//Liver Toxins list
+GLOBAL_LIST_INIT(liver_toxins, list("toxin", "plasma", "sacid", "facid", "cyanide","amanitin", "carpotoxin"))
 
 //Random chem blacklist
-var/global/list/blocked_chems = list("polonium", "initropidril", "concentrated_initro",
+GLOBAL_LIST_INIT(blocked_chems, list("polonium", "initropidril", "concentrated_initro",
 							"sodium_thiopental", "ketamine", "coniine",
 							"adminordrazine", "nanites", "hellwater",
 							"mutationtoxin", "amutationtoxin", "venom",
@@ -55,9 +58,9 @@ var/global/list/blocked_chems = list("polonium", "initropidril", "concentrated_i
 							"syndicate_nanites", "ripping_tendrils", "boiling_oil",
 							"envenomed_filaments", "lexorin_jelly", "kinetic",
 							"cryogenic_liquid", "dark_matter", "b_sorium",
-							"reagent", "life","dragonsbreath", "nanocalcium")
+							"reagent", "life","dragonsbreath", "nanocalcium"))
 
-var/global/list/safe_chem_list = list("antihol", "charcoal", "epinephrine", "insulin", "teporone","silver_sulfadiazine", "salbutamol",
+GLOBAL_LIST_INIT(safe_chem_list, list("antihol", "charcoal", "epinephrine", "insulin", "teporone","silver_sulfadiazine", "salbutamol",
 									  "omnizine", "stimulants", "synaptizine", "potass_iodide", "oculine", "mannitol", "styptic_powder",
 									  "spaceacillin", "salglu_solution", "sal_acid", "cryoxadone", "blood", "synthflesh", "hydrocodone",
-									  "mitocholide", "rezadone")
\ No newline at end of file
+									  "mitocholide", "rezadone"))
\ No newline at end of file
diff --git a/code/game/objects/items/random_items.dm b/code/game/objects/items/random_items.dm
index 906c04ba8c8..e6e6fcfc8a0 100644
--- a/code/game/objects/items/random_items.dm
+++ b/code/game/objects/items/random_items.dm
@@ -51,9 +51,9 @@
 /obj/item/reagent_containers/glass/bottle/random_reagent/New()
 	..()
 	var/list/possible_chems = GLOB.chemical_reagents_list.Copy()
-	possible_chems -= blocked_chems.Copy()
+	possible_chems -= GLOB.blocked_chems.Copy()
 	var/datum/reagent/R = pick(possible_chems)
-	if(rare_chemicals.Find(R))
+	if(GLOB.rare_chemicals.Find(R))
 		reagents.add_reagent(R, 10)
 	else
 		reagents.add_reagent(R, rand(2, 3)*10)
@@ -68,7 +68,7 @@
 /obj/item/reagent_containers/glass/bottle/random_chem/New()
 	..()
 	var/R = get_random_reagent_id()
-	if(rare_chemicals.Find(R))
+	if(GLOB.rare_chemicals.Find(R))
 		reagents.add_reagent(R, 10)
 	else
 		reagents.add_reagent(R, rand(2, 3)*10)
@@ -82,7 +82,7 @@
 
 /obj/item/reagent_containers/glass/bottle/random_base_chem/New()
 	..()
-	var/datum/reagent/R = pick(base_chemicals)
+	var/datum/reagent/R = pick(GLOB.base_chemicals)
 	reagents.add_reagent(R, rand(2, 6)*5)
 	name = "unlabelled bottle"
 	pixel_x = rand(-10, 10)
@@ -94,7 +94,7 @@
 
 /obj/item/reagent_containers/food/drinks/bottle/random_drink/New()
 	..()
-	var/list/possible_drinks = drinks.Copy()
+	var/list/possible_drinks = GLOB.drinks.Copy()
 	if(prob(50))
 		possible_drinks += list("pancuronium","lsd","omnizine","blood")
 
@@ -113,7 +113,7 @@
 	..()
 
 	var/R = get_random_reagent_id()
-	if(rare_chemicals.Find(R))
+	if(GLOB.rare_chemicals.Find(R))
 		reagents.add_reagent(R, 10)
 	else
 		reagents.add_reagent(R, rand(3, 10)*10)
@@ -131,13 +131,13 @@
 /obj/item/storage/pill_bottle/random_meds/New()
 	..()
 	for(var/i in 1 to storage_slots)
-		var/list/possible_medicines = standard_medicines.Copy()
+		var/list/possible_medicines = GLOB.standard_medicines.Copy()
 		if(prob(50))
-			possible_medicines += rare_medicines.Copy()
+			possible_medicines += GLOB.rare_medicines.Copy()
 		var/datum/reagent/R = pick(possible_medicines)
 		var/obj/item/reagent_containers/food/pill/P = new(src)
 
-		if(rare_medicines.Find(R))
+		if(GLOB.rare_medicines.Find(R))
 			P.reagents.add_reagent(R, 10)
 		else
 			P.reagents.add_reagent(R, rand(2, 5)*10)
@@ -182,7 +182,7 @@
 
 /obj/structure/closet/crate/secure/chemicals/New()
 	..()
-	for(var/chem in standard_chemicals)
+	for(var/chem in GLOB.standard_chemicals)
 		var/obj/item/reagent_containers/glass/bottle/B = new(src)
 		B.reagents.add_reagent(chem, B.volume)
 		if(prob(85))
diff --git a/code/modules/food_and_drinks/drinks/drinks.dm b/code/modules/food_and_drinks/drinks/drinks.dm
index e64b74f1635..95de1a3cdf1 100644
--- a/code/modules/food_and_drinks/drinks/drinks.dm
+++ b/code/modules/food_and_drinks/drinks/drinks.dm
@@ -35,7 +35,7 @@
 				var/mob/living/silicon/robot/borg = user
 				borg.cell.use(30)
 				var/refill = reagents.get_master_reagent_id()
-				if(refill in drinks) // Only synthesize drinks
+				if(refill in GLOB.drinks) // Only synthesize drinks
 					spawn(600)
 						reagents.add_reagent(refill, bitesize)
 			return 1
@@ -99,7 +99,7 @@
 		to_chat(user, "<span class='notice'> You transfer [trans] units of the solution to [target].</span>")
 
 		if(isrobot(user)) //Cyborg modules that include drinks automatically refill themselves, but drain the borg's cell
-			if(refill in drinks) // Only synthesize drinks
+			if(refill in GLOB.drinks) // Only synthesize drinks
 				var/mob/living/silicon/robot/bro = user
 				var/chargeAmount = max(30,4*trans)
 				bro.cell.use(chargeAmount)
diff --git a/code/modules/hydroponics/grown/mushrooms.dm b/code/modules/hydroponics/grown/mushrooms.dm
index 56d032045c0..95ea83cd424 100644
--- a/code/modules/hydroponics/grown/mushrooms.dm
+++ b/code/modules/hydroponics/grown/mushrooms.dm
@@ -81,7 +81,7 @@
 /obj/item/reagent_containers/food/snacks/grown/mushroom/angel
 	seed = /obj/item/seeds/angel
 	name = "destroying angel"
-	desc = "<I>Amanita Virosa</I>: Deadly poisonous basidiomycete fungus filled with alpha amatoxins."
+	desc = "<I>Amanita Virosa</I>: Deadly poisonous basidiomycete fungus filled with alpha amanitin."
 	icon_state = "angel"
 	filling_color = "#C0C0C0"
 
diff --git a/code/modules/reagents/chemistry/machinery/chem_master.dm b/code/modules/reagents/chemistry/machinery/chem_master.dm
index d6dc8f91806..81fed023251 100644
--- a/code/modules/reagents/chemistry/machinery/chem_master.dm
+++ b/code/modules/reagents/chemistry/machinery/chem_master.dm
@@ -378,7 +378,7 @@
 /obj/machinery/chem_master/proc/chemical_safety_check(datum/reagents/R)
 	var/all_safe = 1
 	for(var/datum/reagent/A in R.reagent_list)
-		if(!safe_chem_list.Find(A.id))
+		if(!GLOB.safe_chem_list.Find(A.id))
 			all_safe = 0
 	return all_safe
 
diff --git a/code/modules/reagents/chemistry/reagents/toxins.dm b/code/modules/reagents/chemistry/reagents/toxins.dm
index d6813ee6f61..4bc534c6d8b 100644
--- a/code/modules/reagents/chemistry/reagents/toxins.dm
+++ b/code/modules/reagents/chemistry/reagents/toxins.dm
@@ -7,7 +7,7 @@
 
 /datum/reagent/toxin/on_mob_life(mob/living/M)
 	var/update_flags = STATUS_UPDATE_NONE
-	update_flags |= M.adjustToxLoss(2, FALSE)
+	update_flags |= M.adjustToxLoss(2*REAGENTS_EFFECT_MULTIPLIER, FALSE)
 	return ..() | update_flags
 
 /datum/reagent/spider_venom
diff --git a/code/modules/reagents/reagent_containers/hypospray.dm b/code/modules/reagents/reagent_containers/hypospray.dm
index ced02f2e48f..3af51ac50a7 100644
--- a/code/modules/reagents/reagent_containers/hypospray.dm
+++ b/code/modules/reagents/reagent_containers/hypospray.dm
@@ -52,7 +52,7 @@
 	if(safety_hypo && !emagged)
 		var/found_forbidden_reagent = FALSE
 		for(var/datum/reagent/R in reagents.reagent_list)
-			if(!safe_chem_list.Find(R.id))
+			if(!GLOB.safe_chem_list.Find(R.id))
 				reagents.del_reagent(R.id)
 				found_forbidden_reagent = TRUE
 		if(found_forbidden_reagent)
diff --git a/code/modules/surgery/organs/liver.dm b/code/modules/surgery/organs/liver.dm
index bf6f085275b..ba3112b6392 100644
--- a/code/modules/surgery/organs/liver.dm
+++ b/code/modules/surgery/organs/liver.dm
@@ -46,7 +46,7 @@
 					owner.adjustToxLoss(0.1 * PROCESS_ACCURACY)
 
 			// Can't cope with toxins at all
-			for(var/toxin in list("toxin", "plasma", "sacid", "facid", "cyanide", "amanitin", "carpotoxin"))
+			for(var/toxin in GLOB.liver_toxins)
 				if(owner.reagents.has_reagent(toxin))
 					owner.adjustToxLoss(0.3 * PROCESS_ACCURACY)