diff --git a/code/datums/diseases/berserker.dm b/code/datums/diseases/berserker.dm
new file mode 100644
index 00000000000..248503ba672
--- /dev/null
+++ b/code/datums/diseases/berserker.dm
@@ -0,0 +1,55 @@
+/datum/disease/berserker
+	name = "Berserker"
+	max_stages = 2
+	stage_prob = 5
+	spread_text = "Non-Contagious"
+	spread_flags = SPECIAL
+	cure_text = "Anti-Psychotics"
+	cures = list("haloperidol")
+	agent = "Jagged Crystals"
+	cure_chance = 10
+	viable_mobtypes = list(/mob/living/carbon/human)
+	desc = "Swearing, shouting, attacking nearby crew members uncontrollably."
+	severity = DANGEROUS
+	disease_flags = CURABLE
+	spread_flags = NON_CONTAGIOUS
+
+/datum/disease/berserker/stage_act()
+	..()
+	if(affected_mob.reagents.has_reagent("thc"))
+		to_chat(affected_mob, "<span class='notice'>You mellow out.</span>")
+		cure()
+		return
+	switch(stage)
+		if(1)
+			if(prob(5))
+				affected_mob.emote(pick("twitch_s", "grumble"))
+			if(prob(5))
+				var/speak = pick("Grr...", "Fuck...", "Fucking...", "Fuck this fucking.. fuck..")
+				affected_mob.say(speak)
+		if(2)
+			if(prob(5))
+				affected_mob.emote(pick("twitch_s", "scream"))
+			if (prob(5))
+				var/speak = pick("AAARRGGHHH!!!!", "GRR!!!", "FUCK!! FUUUUUUCK!!!", "FUCKING SHITCOCK!!", "WROOAAAGHHH!!")
+				affected_mob.say(speak)
+			if (prob(15))
+				affected_mob.visible_message("<span class='danger'>[affected_mob] twitches violently!</span>")
+				affected_mob.drop_l_hand()
+				affected_mob.drop_r_hand()
+			if (prob(33))
+				if(affected_mob.incapacitated())
+					affected_mob.visible_message("<span class='danger'>[affected_mob] spasms and twitches!</span>")
+					return
+				affected_mob.visible_message("<span class='danger'>[affected_mob] thrashes around violently!</span>")
+				for(var/mob/living/carbon/M in range(1, affected_mob))
+					if(M == affected_mob)
+						continue
+					var/damage = rand(1, 5)
+					if (prob(80))
+						playsound(affected_mob.loc, "punch", 25, 1, -1)
+						affected_mob.visible_message("<span class='danger'>[affected_mob] hits [M] with their thrashing!</span>")
+						M.adjustBruteLoss(damage)
+					else
+						playsound(affected_mob.loc, "sound/weapons/punchmiss.ogg", 25, 1, -1)
+						affected_mob.visible_message("<span class='danger'>[affected_mob] fails to hit [M] with their thrashing!</span>")
\ No newline at end of file
diff --git a/code/modules/mob/mob.dm b/code/modules/mob/mob.dm
index 658959001a1..e5661f10ea5 100644
--- a/code/modules/mob/mob.dm
+++ b/code/modules/mob/mob.dm
@@ -1349,16 +1349,18 @@ mob/proc/yank_out_object()
 		ghost.notify_cloning(message, sound, source)
 		return ghost
 
-/mob/proc/fakevomit(green=0) //for aesthetic vomits that need to be instant and do not stun. -Fox
+/mob/proc/fakevomit(green = 0, no_text = 0) //for aesthetic vomits that need to be instant and do not stun. -Fox
 	if(stat==DEAD)
 		return
 	var/turf/location = loc
 	if (istype(location, /turf/simulated))
 		if(green)
-			src.visible_message("<span class='warning'>[src] vomits up some green goo!</span>","<span class='warning'>You vomit up some green goo!</span>")
+			if(!no_text)
+				visible_message("<span class='warning'>[src] vomits up some green goo!</span>","<span class='warning'>You vomit up some green goo!</span>")
 			new /obj/effect/decal/cleanable/vomit/green(location)
 		else
-			src.visible_message("<span class='warning'>[src] pukes all over \himself!</span>","<span class='warning'>You puke all over yourself!</span>")
+			if(!no_text)
+				visible_message("<span class='warning'>[src] pukes all over \himself!</span>","<span class='warning'>You puke all over yourself!</span>")
 			location.add_vomit_floor(src, 1)
 		playsound(location, 'sound/effects/splat.ogg', 50, 1)
 
diff --git a/code/modules/reagents/newchem/disease.dm b/code/modules/reagents/newchem/disease.dm
index 9c18efe308d..9e2c4d89554 100644
--- a/code/modules/reagents/newchem/disease.dm
+++ b/code/modules/reagents/newchem/disease.dm
@@ -50,6 +50,19 @@
 		M.ForceContractDisease(new /datum/disease/tuberculosis(0))
 	..()
 
+/datum/reagent/jagged_crystals
+	name = "Jagged Crystals"
+	id = "jagged_crystals"
+	description = "Rapid chemical decomposition has warped these crystals into twisted spikes."
+	reagent_state = SOLID
+	color = "#FA0000" // rgb: 250, 0, 0
+
+/datum/reagent/jagged_crystals/on_mob_life(var/mob/living/carbon/M as mob)
+	if(!M) M = holder.my_atom
+	M.ForceContractDisease(new /datum/disease/berserker(0))
+	..()
+
+
 /datum/reagent/spore
 	name = "Blob Spores"
 	id = "spore"
diff --git a/code/modules/reagents/newchem/drugs.dm b/code/modules/reagents/newchem/drugs.dm
index 6d8a7d4117f..5ca177cb48e 100644
--- a/code/modules/reagents/newchem/drugs.dm
+++ b/code/modules/reagents/newchem/drugs.dm
@@ -26,11 +26,45 @@
 	..()
 	return
 
-/datum/reagent/nicotine/overdose_process(var/mob/living/M as mob)
-	M.adjustToxLoss(1*REM)
-	M.adjustOxyLoss(1*REM)
-	..()
-	return
+/datum/reagent/nicotine/overdose_process(var/mob/living/M as mob, severity)
+	var/effect = ..()
+	if(severity == 1)
+		if(effect <= 2)
+			M.visible_message("<span class='warning'>[M] looks nervous!</span>")
+			M.confused += 15
+			M.adjustToxLoss(2)
+			M.Jitter(10)
+			M.emote("twitch_s")
+		else if(effect <= 4)
+			M.visible_message("<span class='warning'>[M] is all sweaty!</span>")
+			M.bodytemperature += rand(15,30)
+			M.adjustToxLoss(3)
+		else if(effect <= 7)
+			M.adjustToxLoss(4)
+			M.emote("twitch")
+			M.Jitter(10)
+	else if(severity == 2)
+		if(effect <= 2)
+			M.emote("gasp")
+			to_chat(M, "<span class='warning'>You can't breathe!</span>")
+			M.adjustOxyLoss(15)
+			M.adjustToxLoss(3)
+			M.Stun(1)
+		else if(effect <= 4)
+			to_chat(M, "<span class='warning'>You feel terrible!</span>")
+			M.emote("drool")
+			M.Jitter(10)
+			M.adjustToxLoss(5)
+			M.Weaken(1)
+			M.confused += 33
+		else if(effect <= 7)
+			M.emote("collapse")
+			to_chat(M, "<span class='warning'>Your heart is pounding!</span>")
+			M << sound('sound/goonstation/effects/heartbeat.ogg')
+			M.Paralyse(5)
+			M.Jitter(30)
+			M.adjustToxLoss(6)
+			M.adjustOxyLoss(20)
 
 /datum/reagent/crank
 	name = "Crank"
@@ -62,12 +96,45 @@
 		M.emote(pick("groan", "moan"))
 	..()
 	return
-/datum/reagent/crank/overdose_process(var/mob/living/M as mob)
-	M.adjustBrainLoss(rand(1,10)*REM)
-	M.adjustToxLoss(rand(1,10)*REM)
-	M.adjustBruteLoss(rand(1,10)*REM)
-	..()
-	return
+
+/datum/reagent/crank/overdose_process(var/mob/living/M as mob, severity)
+	var/effect = ..()
+	if(severity == 1)
+		if(effect <= 2)
+			M.visible_message("<span class='warning'>[M] looks confused!</span>")
+			M.confused += 20
+			M.Jitter(20)
+			M.emote("scream")
+		else if(effect <= 4)
+			M.visible_message("<span class='warning'>[M] is all sweaty!</span>")
+			M.bodytemperature += rand(5,30)
+			M.adjustBrainLoss(1)
+			M.adjustToxLoss(1)
+			M.Stun(2)
+		else if(effect <= 7)
+			M.Jitter(30)
+			M.emote("grumble")
+	else if(severity == 2)
+		if(effect <= 2)
+			M.visible_message("<span class='warning'>[M] is sweating like a pig!</span>")
+			M.bodytemperature += rand(20,100)
+			M.adjustToxLoss(5)
+			M.Stun(3)
+		else if(effect <= 4)
+			M.visible_message("<span class='warning'>[M] starts tweaking the hell out!</span>")
+			M.Jitter(100)
+			M.adjustToxLoss(2)
+			M.adjustBrainLoss(8)
+			M.Weaken(3)
+			M.confused += 25
+			M.emote("scream")
+			M.reagents.add_reagent("jagged_crystals", 5)
+		else if(effect <= 7)
+			M.emote("scream")
+			M.visible_message("<span class='warning'>[M] nervously scratches at their skin!</span>")
+			M.Jitter(10)
+			M.adjustBruteLoss(5)
+			M.emote("twitch_s")
 
 /datum/chemical_reaction/crank
 	name = "Crank"
@@ -120,12 +187,40 @@
 	..()
 	return
 
-/datum/reagent/krokodil/overdose_process(var/mob/living/M as mob)
-	if(prob(10))
-		M.adjustBrainLoss(rand(1,5)*REM)
-		M.adjustToxLoss(rand(1,5)*REM)
-	..()
-	return
+/datum/reagent/krokodil/overdose_process(var/mob/living/M as mob, severity)
+	var/effect = ..()
+	if(severity == 1)
+		if(effect <= 2)
+			M.visible_message("<span class='warning'>[M] looks dazed!</span>")
+			M.Stun(3)
+			M.emote("drool")
+		else if(effect <= 4)
+			M.emote("shiver")
+			M.bodytemperature -= 40
+		else if(effect <= 7)
+			to_chat(M, "<span class='warning'>Your skin is cracking and bleeding!</span>")
+			M.adjustBruteLoss(5)
+			M.adjustToxLoss(2)
+			M.adjustBrainLoss(1)
+			M.emote("cry")
+	else if(severity == 2)
+		if(effect <= 2)
+			M.visible_message("<span class='warning'>[M]</b> sways and falls over!</span>")
+			M.adjustToxLoss(3)
+			M.adjustBrainLoss(3)
+			M.Weaken(8)
+			M.emote("faint")
+		else if(effect <= 4)
+			if(ishuman(M))
+				var/mob/living/carbon/human/H = M
+				H.visible_message("<span class='warning'>[M]'s skin is rotting away!</span>")
+				H.adjustBruteLoss(25)
+				H.emote("scream")
+				H.ChangeToHusk()
+				H.emote("faint")
+		else if(effect <= 7)
+			M.emote("shiver")
+			M.bodytemperature -= 70
 
 /datum/chemical_reaction/krokodil
 	name = "Krokodil"
@@ -169,19 +264,30 @@
 	..()
 	return
 
-/datum/reagent/methamphetamine/overdose_process(var/mob/living/M as mob)
-	if(prob(20))
-		M.emote("laugh")
-	if(prob(33))
-		M.visible_message("<span class='danger'>[M]'s hands flip out and flail everywhere!</span>")
-		var/obj/item/I = M.get_active_hand()
-		if(I)
-			M.drop_item()
-	..()
-	if(prob(50))
-		M.adjustToxLoss(10)
-	M.adjustBrainLoss(pick(0.5, 0.6, 0.7, 0.8, 0.9, 1))
-	return
+/datum/reagent/methamphetamine/overdose_process(var/mob/living/M as mob, severity)
+	var/effect = ..()
+	if(severity == 1)
+		if(effect <= 2)
+			M.visible_message("<span class='warning'>[M] can't seem to control their legs!</span>")
+			M.confused += 20
+			M.Weaken(4)
+		else if(effect <= 4)
+			M.visible_message("<span class='warning'>[M]'s hands flip out and flail everywhere!</span>")
+			M.drop_l_hand()
+			M.drop_r_hand()
+		else if(effect <= 7)
+			M.emote("laugh")
+	else if(severity == 2)
+		if(effect <= 2)
+			M.visible_message("<span class='warning'>[M]'s hands flip out and flail everywhere!</span>")
+			M.drop_l_hand()
+			M.drop_r_hand()
+		else if(effect <= 4)
+			M.visible_message("<span class='warning'>[M] falls to the floor and flails uncontrollably!</span>")
+			M.Jitter(10)
+			M.Weaken(10)
+		else if(effect <= 7)
+			M.emote("laugh")
 
 /datum/chemical_reaction/methamphetamine
 	name = "methamphetamine"
@@ -255,7 +361,7 @@
 	mix_message = "Tiny cubic crystals precipitate out of the mixture. Huh."
 	mix_sound = 'sound/goonstation/misc/fuse.ogg'
 
-/datum/reagent/bath_salts/overdose_process(var/mob/living/M as mob)
+/datum/reagent/bath_salts/overdose_process(var/mob/living/M as mob, severity)
 	M.hallucination += 10
 	if(M.canmove && !istype(M.loc, /turf/space))
 		for(var/i = 0, i < 8, i++)
@@ -266,7 +372,6 @@
 		var/obj/item/I = M.get_active_hand()
 		if(I)
 			M.drop_item()
-	..()
 	return
 
 /datum/chemical_reaction/aranesp
@@ -381,24 +486,30 @@
 /datum/reagent/fliptonium/reagent_deleted(var/mob/living/M as mob)
 	M.SpinAnimation(speed = 12, loops = -1)
 
-/datum/reagent/fliptonium/overdose_process(var/mob/living/M as mob)
-	if(volume > 15)
-		if(prob(5))
-			switch(pick(1, 2, 3))
-				if(1)
-					M.emote("laugh")
-					M.adjustToxLoss(1)
-				if(2)
-					to_chat(M, "<span class='danger'>[M] can't seem to control their legs!</span>")
-					M.Weaken(8)
-					M.adjustToxLoss(1)
-				if(3)
-					to_chat(M, "<span class='danger'>[M]'s hands flip out and flail everywhere!</span>")
-					M.drop_l_hand()
-					M.drop_r_hand()
-					M.adjustToxLoss(1)
-	..()
-	return
+/datum/reagent/fliptonium/overdose_process(var/mob/living/M as mob, severity)
+	var/effect = ..()
+	if(severity == 1)
+		if(effect <= 2)
+			M.visible_message("<span class='warning'>[M] can't seem to control their legs!</span>")
+			M.confused += 33
+			M.Weaken(2)
+		else if(effect <= 4)
+			M.visible_message("<span class='warning'>[M]'s hands flip out and flail everywhere!</span>")
+			M.drop_l_hand()
+			M.drop_r_hand()
+		else if(effect <= 7)
+			M.emote("laugh")
+	else if(severity == 2)
+		if(effect <= 2)
+			M.visible_message("<span class='warning'>[M]'s hands flip out and flail everywhere!</span>")
+			M.drop_l_hand()
+			M.drop_r_hand()
+		else if (effect <= 4)
+			M.visible_message("<span class='warning'>[M] falls to the floor and flails uncontrollably!</span>")
+			M.Jitter(5)
+			M.Weaken(5)
+		else if(effect <= 7)
+			M.emote("laugh")
 
 //////////////////////////////
 //		Synth-Drugs			//
@@ -445,7 +556,7 @@
 	..()
 	return
 
-/datum/reagent/lube/ultra/overdose_process(var/mob/living/M as mob)
+/datum/reagent/lube/ultra/overdose_process(var/mob/living/M as mob, severity)
 	if(prob(20))
 		M.emote("ping")
 	if(prob(33))
@@ -457,7 +568,6 @@
 	if(prob(50))
 		M.adjustFireLoss(10)
 	M.adjustBrainLoss(pick(0.5, 0.6, 0.7, 0.8, 0.9, 1))
-	return
 
 //Surge: Krokodil
 /datum/reagent/surge
@@ -484,7 +594,7 @@
 	..()
 	return
 
-/datum/reagent/surge/overdose_process(var/mob/living/M as mob)
+/datum/reagent/surge/overdose_process(var/mob/living/M as mob, severity)
 	//Hit them with the same effects as an electrode!
 	M.Stun(5)
 	M.Weaken(5)
@@ -502,8 +612,6 @@
 		B.icon = I
 		M.adjustFireLoss(rand(1,5)*REM)
 		M.adjustBruteLoss(rand(1,5)*REM)
-	..()
-	return
 
 /datum/chemical_reaction/surge
 	name = "Surge"
diff --git a/code/modules/reagents/newchem/food.dm b/code/modules/reagents/newchem/food.dm
index 6dd18d307f7..a2f259242e8 100644
--- a/code/modules/reagents/newchem/food.dm
+++ b/code/modules/reagents/newchem/food.dm
@@ -175,15 +175,12 @@ datum/reagent/mugwort/on_mob_life(var/mob/living/M as mob)
 	metabolization_rate = 0.2
 	overdose_threshold = 133
 
-datum/reagent/porktonium/overdose_process(var/mob/living/M as mob)
-	if(volume > 133)
-		if(prob(15))
-			M.reagents.add_reagent("cholesterol", rand(1,3))
-		if(prob(8))
-			M.reagents.add_reagent("radium", 15)
-			M.reagents.add_reagent("cyanide", 10)
-	..()
-	return
+/datum/reagent/porktonium/overdose_process(var/mob/living/M as mob, severity)
+	if(prob(15))
+		M.reagents.add_reagent("cholesterol", rand(1,3))
+	if(prob(8))
+		M.reagents.add_reagent("radium", 15)
+		M.reagents.add_reagent("cyanide", 10)
 
 /datum/reagent/fungus
 	name = "Space fungus"
@@ -283,11 +280,10 @@ datum/reagent/cheese/reaction_turf(var/turf/T, var/volume)
 	color = "#B2B139"
 	overdose_threshold = 50
 
-/datum/reagent/fake_cheese/overdose_process(var/mob/living/M as mob)
+/datum/reagent/fake_cheese/overdose_process(var/mob/living/M as mob, severity)
 	if(prob(8))
 		to_chat(M, "<span class='warning'>You feel something squirming in your stomach. Your thoughts turn to cheese and you begin to sweat.</span>")
 		M.adjustToxLoss(rand(1,2))
-	..()
 
 /datum/reagent/weird_cheese
 	name = "Weird cheese"
@@ -442,7 +438,7 @@ datum/reagent/ectoplasm/reaction_turf(var/turf/T, var/volume)
 	..()
 	return
 
-/datum/reagent/hydrogenated_soybeanoil/overdose_process(var/mob/living/M as mob)
+/datum/reagent/hydrogenated_soybeanoil/overdose_process(var/mob/living/M as mob, severity)
 	if(prob(33))
 		to_chat(M, "<span class='warning'>You feel horribly weak.</span>")
 	if(prob(10))
@@ -453,7 +449,6 @@ datum/reagent/ectoplasm/reaction_turf(var/turf/T, var/volume)
 		M.adjustOxyLoss(25)
 		M.Stun(5)
 		M.Paralyse(10)
-	..()
 
 /datum/chemical_reaction/hydrogenated_soybeanoil
 	name = "Partially hydrogenated space-soybean oil"
diff --git a/code/modules/reagents/newchem/medicine.dm b/code/modules/reagents/newchem/medicine.dm
index 90980c3a421..bc319a9b6bd 100644
--- a/code/modules/reagents/newchem/medicine.dm
+++ b/code/modules/reagents/newchem/medicine.dm
@@ -65,6 +65,7 @@ datum/reagent/salglu_solution
 	description = "This saline and glucose solution can help stabilize critically injured patients and cleanse wounds."
 	reagent_state = LIQUID
 	color = "#C8A5DC"
+	penetrates_skin = 1
 	metabolization_rate = 0.15
 
 datum/reagent/salglu_solution/on_mob_life(var/mob/living/M as mob)
@@ -170,7 +171,7 @@ datum/reagent/omnizine
 	overdose_threshold = 30
 	addiction_chance = 5
 
-datum/reagent/omnizine/on_mob_life(var/mob/living/M as mob)
+/datum/reagent/omnizine/on_mob_life(var/mob/living/M as mob)
 	if(!M) M = holder.my_atom
 	M.adjustToxLoss(-1*REM)
 	M.adjustOxyLoss(-1*REM)
@@ -181,13 +182,39 @@ datum/reagent/omnizine/on_mob_life(var/mob/living/M as mob)
 	..()
 	return
 
-datum/reagent/omnizine/overdose_process(var/mob/living/M as mob)
-	M.adjustToxLoss(3*REM)
-	M.adjustOxyLoss(3*REM)
-	M.adjustBruteLoss(3*REM)
-	M.adjustFireLoss(3*REM)
-	..()
-	return
+/datum/reagent/omnizine/overdose_process(var/mob/living/M as mob, severity)
+	var/effect = ..()
+	if(severity == 1) //lesser
+		M.stuttering += 1
+		if(effect <= 1)
+			M.visible_message("<span class='warning'>[M] suddenly cluches their gut!</span>")
+			M.emote("scream")
+			M.Stun(4)
+			M.Weaken(4)
+		else if(effect <= 3)
+			M.visible_message("<span class='warning'>[M] completely spaces out for a moment.</span>")
+			M.confused += 15
+		else if(effect <= 5)
+			M.visible_message("<span class='warning'>[M] stumbles and staggers.</span>")
+			M.Dizzy(5)
+			M.Weaken(3)
+		else if(effect <= 7)
+			M.visible_message("<span class='warning'>[M] shakes uncontrollably.</span>")
+			M.Jitter(30)
+	else if(severity == 2) // greater
+		if(effect <= 2)
+			M.visible_message("<span class='warning'>[M] suddenly cluches their gut!</span>")
+			M.emote("scream")
+			M.Stun(7)
+			M.Weaken(7)
+		else if(effect <= 5)
+			M.visible_message("<span class='warning'>[M] jerks bolt upright, then collapses!</span>")
+			M.Paralyse(5)
+			M.Weaken(4)
+		else if(effect <= 8)
+			M.visible_message("<span class='warning'>[M] stumbles and staggers.</span>")
+			M.Dizzy(5)
+			M.Weaken(3)
 
 datum/reagent/calomel
 	name = "Calomel"
@@ -290,13 +317,6 @@ datum/reagent/sal_acid/on_mob_life(var/mob/living/M as mob)
 	..()
 	return
 
-datum/reagent/sal_acid/overdose_process(var/mob/living/M as mob)
-	if(volume > 25)
-		if(prob(8))
-			M.adjustToxLoss(rand(1,2))
-	..()
-	return
-
 /datum/chemical_reaction/sal_acid
 	name = "Salicyclic Acid"
 	id = "sal_acid"
@@ -361,17 +381,17 @@ datum/reagent/perfluorodecalin/on_mob_life(var/mob/living/carbon/human/M as mob)
 	mix_message = "The mixture rapidly turns into a dense pink liquid."
 	mix_sound = 'sound/goonstation/misc/drinkfizz.ogg'
 
-datum/reagent/ephedrine
+/datum/reagent/ephedrine
 	name = "Ephedrine"
 	id = "ephedrine"
 	description = "Ephedrine is a plant-derived stimulant."
 	reagent_state = LIQUID
 	color = "#C8A5DC"
 	metabolization_rate = 0.3
-	overdose_threshold = 45
+	overdose_threshold = 35
 	addiction_chance = 25
 
-datum/reagent/ephedrine/on_mob_life(var/mob/living/M as mob)
+/datum/reagent/ephedrine/on_mob_life(var/mob/living/M as mob)
 	if(!M) M = holder.my_atom
 	M.drowsyness = max(0, M.drowsyness-5)
 	M.AdjustParalysis(-1)
@@ -389,12 +409,26 @@ datum/reagent/ephedrine/on_mob_life(var/mob/living/M as mob)
 	..()
 	return
 
-datum/reagent/ephedrine/overdose_process(var/mob/living/M as mob)
-	if(prob(33))
-		M.adjustToxLoss(1*REM)
-		M.losebreath++
-	..()
-	return
+/datum/reagent/ephedrine/overdose_process(var/mob/living/M as mob, severity)
+	var/effect = ..()
+	if(severity == 1)
+		if(effect <= 1)
+			M.visible_message("<span class='warning'>[M] suddenly and violently vomits!</span>")
+			M.fakevomit(no_text = 1)
+		else if(effect <= 3)
+			M.emote(pick("groan","moan"))
+		if(effect <= 8)
+			M.emote("collapse")
+	else if(severity == 2)
+		if(effect <= 2)
+			M.visible_message("<span class='warning'>[M] suddenly and violently vomits!</span>")
+			M.fakevomit(no_text = 1)
+		else if(effect <= 5)
+			M.visible_message("<span class='warning'>[M.name] staggers and drools, their eyes bloodshot!</span>")
+			M.Dizzy(2)
+			M.Weaken(3)
+		if(effect <= 15)
+			M.emote("collapse")
 
 /datum/chemical_reaction/ephedrine
 	name = "Ephedrine"
@@ -441,7 +475,7 @@ datum/reagent/morphine
 	description = "A strong but highly addictive opiate painkiller with sedative side effects."
 	reagent_state = LIQUID
 	color = "#C8A5DC"
-	overdose_threshold = 30
+	overdose_threshold = 20
 	addiction_chance = 50
 	shock_reduction = 50
 
@@ -464,16 +498,6 @@ datum/reagent/morphine/on_mob_life(var/mob/living/M as mob)
 	..()
 	return
 
-datum/reagent/morphine/overdose_process(var/mob/living/M as mob)
-	if(prob(33))
-		var/obj/item/I = M.get_active_hand()
-		if(I)
-			M.drop_item()
-		M.Dizzy(1)
-		M.Jitter(1)
-	..()
-	return
-
 datum/reagent/oculine/on_mob_life(var/mob/living/M as mob)
 	if(!M) M = holder.my_atom
 	if(prob(80))
@@ -519,7 +543,7 @@ datum/reagent/atropine
 	reagent_state = LIQUID
 	color = "#000000"
 	metabolization_rate = 0.2
-	overdose_threshold = 35
+	overdose_threshold = 25
 
 datum/reagent/atropine/on_mob_life(var/mob/living/M as mob)
 	if(!M) M = holder.my_atom
@@ -541,14 +565,6 @@ datum/reagent/atropine/on_mob_life(var/mob/living/M as mob)
 	..()
 	return
 
-datum/reagent/atropine/overdose_process(var/mob/living/M as mob)
-	if(prob(50))
-		M.adjustToxLoss(2*REM)
-		M.Dizzy(1)
-		M.Jitter(1)
-	..()
-	return
-
 /datum/chemical_reaction/atropine
 	name = "Atropine"
 	id = "atropine"
@@ -564,7 +580,7 @@ datum/reagent/epinephrine
 	reagent_state = LIQUID
 	color = "#96B1AE"
 	metabolization_rate = 0.2
-	overdose_threshold = 30
+	overdose_threshold = 20
 
 datum/reagent/epinephrine/on_mob_life(var/mob/living/M as mob)
 	if(!M) M = holder.my_atom
@@ -591,13 +607,26 @@ datum/reagent/epinephrine/on_mob_life(var/mob/living/M as mob)
 	..()
 	return
 
-datum/reagent/epinephrine/overdose_process(var/mob/living/M as mob)
-	if(prob(33))
-		M.adjustStaminaLoss(5*REM)
-		M.adjustToxLoss(2*REM)
-		M.losebreath++
-	..()
-	return
+/datum/reagent/epinephrine/overdose_process(var/mob/living/M as mob, severity)
+	var/effect = ..()
+	if (severity == 1)
+		if(effect <= 1)
+			M.visible_message("<span class='warning'>[M] suddenly and violently vomits!</span>")
+			M.fakevomit(no_text = 1)
+		else if(effect <= 3)
+			M.emote(pick("groan","moan"))
+		if(effect <= 8)
+			M.emote("collapse")
+	else if(severity == 2)
+		if(effect <= 2)
+			M.visible_message("<span class='warning'>[M] suddenly and violently vomits!</span>")
+			M.fakevomit(no_text = 1)
+		else if(effect <= 5)
+			M.visible_message("<span class='warning'>[M] staggers and drools, their eyes bloodshot!</span>")
+			M.Dizzy(2)
+			M.Weaken(3)
+		if(effect <= 15)
+			M.emote("collapse")
 
 /datum/chemical_reaction/epinephrine
 	name = "Epinephrine"
@@ -812,13 +841,11 @@ datum/reagent/stimulants/reagent_deleted(var/mob/living/M as mob)
 	M.adjustStaminaLoss(-5*REM)
 	..()
 
-/datum/reagent/medicine/stimulative_agent/overdose_process(mob/living/M)
+/datum/reagent/medicine/stimulative_agent/overdose_process(mob/living/M, severity)
 	if(prob(33))
 		M.adjustStaminaLoss(2.5*REM)
 		M.adjustToxLoss(1*REM)
 		M.losebreath++
-	..()
-	return
 
 datum/reagent/insulin
 	name = "Insulin"
@@ -855,6 +882,7 @@ datum/reagent/teporone
 	reagent_state = LIQUID
 	color = "#D782E6"
 	addiction_chance = 20
+	overdose_threshold = 50
 
 datum/reagent/teporone/on_mob_life(var/mob/living/M as mob)
 	if(!M) M = holder.my_atom
diff --git a/code/modules/reagents/newchem/newchem_procs.dm b/code/modules/reagents/newchem/newchem_procs.dm
index 97516f916c9..8f3fa6204d2 100644
--- a/code/modules/reagents/newchem/newchem_procs.dm
+++ b/code/modules/reagents/newchem/newchem_procs.dm
@@ -51,14 +51,15 @@
 				continue
 		//If you got this far, that means we can process whatever reagent this iteration is for. Handle things normally from here.
 		if(M && R)
+			R.on_mob_life(M)
 			if(R.volume >= R.overdose_threshold && !R.overdosed && R.overdose_threshold > 0)
 				R.overdosed = 1
 				R.overdose_start(M)
 			if(R.volume < R.overdose_threshold && R.overdosed)
 				R.overdosed = 0
 			if(R.overdosed)
-				R.overdose_process(M)
-			R.on_mob_life(M)
+				R.overdose_process(M, R.volume >= R.overdose_threshold*2 ? 2 : 1)
+
 	for(var/A in addiction_list)
 		var/datum/reagent/R = A
 		if(M && R)
@@ -117,8 +118,11 @@
 	return
 
 // Called if the reagent has passed the overdose threshold and is set to be triggering overdose effects
-/datum/reagent/proc/overdose_process(var/mob/living/M as mob)
-	return
+/datum/reagent/proc/overdose_process(var/mob/living/M as mob, severity)
+	var/effect = rand(1, 100) - severity
+	if (effect <= 8)
+		M.adjustToxLoss(severity)
+	return effect
 
 /datum/reagent/proc/overdose_start(var/mob/living/M as mob)
 	return
diff --git a/code/modules/reagents/newchem/toxins.dm b/code/modules/reagents/newchem/toxins.dm
index b602e282b1f..e331f4d3565 100644
--- a/code/modules/reagents/newchem/toxins.dm
+++ b/code/modules/reagents/newchem/toxins.dm
@@ -55,23 +55,45 @@
 	..()
 	return
 
-/datum/reagent/histamine/overdose_process(var/mob/living/M as mob)
-	if(prob(2))
-		to_chat(M, "<span class='danger'>You feel mucus running down the back of your throat.</span>")
-		M.adjustToxLoss(1)
-		M.jitteriness += 4
-		M.emote("sneeze", "cough")
-	else if(prob(4))
-		M.stuttering += rand(0,5)
-		if(prob(25))
-			M.emote(pick("choke","gasp"))
-			M.adjustOxyLoss(5)
-	else if(prob(7))
-		to_chat(M, "<span class='danger'>Your chest hurts!</span>")
-		M.emote(pick("cough","gasp"))
-		M.adjustOxyLoss(3)
-	..()
-	return
+/datum/reagent/histamine/overdose_process(var/mob/living/M as mob, severity)
+	var/effect = ..()
+	if(severity == 1)
+		if(effect <= 2)
+			to_chat(M, "<span class='warning'>You feel mucus running down the back of your throat.</span>")
+			M.adjustToxLoss(1)
+			M.Jitter(4)
+			M.emote(pick("sneeze", "cough"))
+		else if(effect <= 4)
+			M.stuttering += rand(0,5)
+			if(prob(25))
+				M.emote(pick("choke","gasp"))
+				M.adjustOxyLoss(5)
+		else if(effect <= 7)
+			to_chat(M, "<span class='warning'>Your chest hurts!</span>")
+			M.emote(pick("cough","gasp"))
+			M.adjustOxyLoss(3)
+	else if(severity == 2)
+		if(effect <= 2)
+			M.visible_message("<span class='warning'>[M] breaks out in hives!</span>")
+			M.adjustBruteLoss(6)
+		else if(effect <= 4)
+			M.visible_message("<span class='warning'>[M] has a horrible coughing fit!</span>")
+			M.Jitter(10)
+			M.stuttering += rand(0,5)
+			M.emote("cough")
+			if(prob(40))
+				M.emote(pick("choke","gasp"))
+				M.adjustOxyLoss(6)
+			M.Weaken(8)
+		else if(effect <= 7)
+			to_chat(M, "<span class='warning'>Your heartbeat is pounding inside your head!</span>")
+			M.playsound_local(M.loc, "sound/goonstation/effects/heartbeat.ogg", 50, 1)
+			M.emote("collapse")
+			M.adjustOxyLoss(8)
+			M.adjustToxLoss(3)
+			M.Weaken(3)
+			M.emote(pick("choke", "gasp"))
+			to_chat(M, "<span class='warning'>You feel like you're dying!</span>")
 
 /datum/reagent/formaldehyde
 	name = "Formaldehyde"
@@ -130,8 +152,6 @@
 			M.jitteriness += 1000
 			spawn(rand(20, 100))
 				M.gib()
-	..()
-	return
 
 /datum/reagent/neurotoxin2
 	name = "Neurotoxin"
diff --git a/code/modules/reagents/oldchem/reagents/drink/reagents_alcohol.dm b/code/modules/reagents/oldchem/reagents/drink/reagents_alcohol.dm
index 2d85730193f..12e1a554edd 100644
--- a/code/modules/reagents/oldchem/reagents/drink/reagents_alcohol.dm
+++ b/code/modules/reagents/oldchem/reagents/drink/reagents_alcohol.dm
@@ -151,10 +151,8 @@
 	..()
 	return
 
-/datum/reagent/ethanol/absinthe/overdose_process(mob/living/M)
+/datum/reagent/ethanol/absinthe/overdose_process(mob/living/M, severity)
 	M.adjustToxLoss(1)
-	..()
-	return
 
 /datum/reagent/ethanol/rum
 	name = "Rum"
@@ -169,10 +167,8 @@
 	M.dizziness +=5
 	return
 
-/datum/reagent/ethanol/rum/overdose_process(mob/living/M)
+/datum/reagent/ethanol/rum/overdose_process(mob/living/M, severity)
 	M.adjustToxLoss(1)
-	..()
-	return
 
 /datum/reagent/ethanol/mojito
 	name = "Mojito"
diff --git a/code/modules/reagents/oldchem/reagents/drink/reagents_drink.dm b/code/modules/reagents/oldchem/reagents/drink/reagents_drink.dm
index 9daf9cb9ec1..45e0e2e8ac2 100644
--- a/code/modules/reagents/oldchem/reagents/drink/reagents_drink.dm
+++ b/code/modules/reagents/oldchem/reagents/drink/reagents_drink.dm
@@ -201,13 +201,10 @@
 	..()
 	return
 
-/datum/reagent/drink/coffee/overdose_process(var/mob/living/M as mob)
+/datum/reagent/drink/coffee/overdose_process(var/mob/living/M as mob, severity)
 	if(volume > 45)
 		M.Jitter(5)
 
-	..()
-	return
-
 /datum/reagent/drink/coffee/icecoffee
 	name = "Iced Coffee"
 	id = "icecoffee"
diff --git a/code/modules/reagents/oldchem/reagents/reagents_food.dm b/code/modules/reagents/oldchem/reagents/reagents_food.dm
index 05a3fad7808..4c284d7d7cc 100644
--- a/code/modules/reagents/oldchem/reagents/reagents_food.dm
+++ b/code/modules/reagents/oldchem/reagents/reagents_food.dm
@@ -167,13 +167,11 @@
 	description = "Sodium chloride, common table salt."
 	reagent_state = SOLID
 	color = "#B1B0B0"
+	overdose_threshold = 100
 
-/datum/reagent/sodiumchloride/overdose_process(var/mob/living/M as mob)
-	if(volume > 100)
-		if(prob(70))
-			M.adjustBrainLoss(1)
-		if(prob(8))
-			M.adjustToxLoss(rand(1,2))
+/datum/reagent/sodiumchloride/overdose_process(var/mob/living/M as mob, severity)
+	if(prob(70))
+		M.adjustBrainLoss(1)
 	..()
 	return
 
@@ -454,11 +452,9 @@
 	M.emote("collapse")
 	..()
 
-/datum/reagent/sugar/overdose_process(var/mob/living/M as mob)
-	if(volume > 200)
-		M.Paralyse(3)
-		M.Weaken(4)
-		if(prob(8))
-			M.adjustToxLoss(1)
-	..()
-	return
+/datum/reagent/sugar/overdose_process(var/mob/living/M as mob, severity)
+	M.Paralyse(3 * severity)
+	M.Weaken(4 * severity)
+	if(prob(8))
+		M.adjustToxLoss(severity)
+
diff --git a/code/modules/reagents/oldchem/reagents/reagents_med.dm b/code/modules/reagents/oldchem/reagents/reagents_med.dm
index 64e3b00936d..0a2fa0396bf 100644
--- a/code/modules/reagents/oldchem/reagents/reagents_med.dm
+++ b/code/modules/reagents/oldchem/reagents/reagents_med.dm
@@ -40,6 +40,7 @@
 	description = "Synaptizine is used to treat neuroleptic shock. Can be used to help remove disabling symptoms such as paralysis."
 	reagent_state = LIQUID
 	color = "#FA46FA"
+	overdose_threshold = 40
 
 /datum/reagent/synaptizine/on_mob_life(var/mob/living/M as mob)
 	if(!M) M = holder.my_atom
@@ -53,6 +54,27 @@
 	..()
 	return
 
+/datum/reagent/synaptizine/overdose_process(var/mob/living/M as mob, severity)
+	var/effect = ..()
+	if(severity == 1)
+		if(effect <= 1)
+			M.visible_message("<span class='warning'>[M] suddenly and violently vomits!</span>")
+			M.fakevomit(no_text = 1)
+		else if(effect <= 3)
+			M.emote(pick("groan","moan"))
+		if(effect <= 8)
+			M.adjustToxLoss(1)
+	else if(severity == 2)
+		if(effect <= 2)
+			M.visible_message("<span class='warning'>[M] suddenly and violently vomits!</span>")
+			M.fakevomit(no_text = 1)
+		else if(effect <= 5)
+			M.visible_message("<span class='warning'>[M] staggers and drools, their eyes bloodshot!</span>")
+			M.Dizzy(8)
+			M.Weaken(4)
+		if(effect <= 15)
+			M.adjustToxLoss(1)
+
 /datum/reagent/mitocholide
 	name = "Mitocholide"
 	id = "mitocholide"
@@ -114,12 +136,10 @@
 	..()
 	return
 
-/datum/reagent/rezadone/overdose_process(mob/living/M)
+/datum/reagent/rezadone/overdose_process(mob/living/M, severity)
 	M.adjustToxLoss(1)
 	M.Dizzy(5)
 	M.Jitter(5)
-	..()
-	return
 
 /datum/reagent/spaceacillin
 	name = "Spaceacillin"
diff --git a/paradise.dme b/paradise.dme
index 9077d8b86f4..cab6d3172c7 100644
--- a/paradise.dme
+++ b/paradise.dme
@@ -213,6 +213,7 @@
 #include "code\datums\diseases\anxiety.dm"
 #include "code\datums\diseases\appendicitis.dm"
 #include "code\datums\diseases\beesease.dm"
+#include "code\datums\diseases\berserker.dm"
 #include "code\datums\diseases\brainrot.dm"
 #include "code\datums\diseases\cold.dm"
 #include "code\datums\diseases\cold9.dm"
diff --git a/sound/goonstation/effects/heartbeat.ogg b/sound/goonstation/effects/heartbeat.ogg
new file mode 100644
index 00000000000..a98aec8037a
Binary files /dev/null and b/sound/goonstation/effects/heartbeat.ogg differ