diff --git a/code/modules/reagents/chemistry/machinery/chem_master.dm b/code/modules/reagents/chemistry/machinery/chem_master.dm
index a4578d9c1e3..90f9ed47eec 100644
--- a/code/modules/reagents/chemistry/machinery/chem_master.dm
+++ b/code/modules/reagents/chemistry/machinery/chem_master.dm
@@ -202,6 +202,9 @@
 					return
 				name = reject_bad_text(name)
 				while(count--)
+					if(reagents.total_volume <= 0)
+						to_chat(usr, "<span class='notice'>Not enough reagents to create these pills!</span>")
+						return
 					var/obj/item/reagent_containers/food/pill/P = new/obj/item/reagent_containers/food/pill(loc)
 					if(!name) name = reagents.get_master_reagent_name()
 					P.name = "[name] pill"