diff --git a/code/modules/reagents/chemistry/reagents/misc_reagents.dm b/code/modules/reagents/chemistry/reagents/misc_reagents.dm
index 3c64adf2b7e..8f0d5a5b480 100644
--- a/code/modules/reagents/chemistry/reagents/misc_reagents.dm
+++ b/code/modules/reagents/chemistry/reagents/misc_reagents.dm
@@ -514,8 +514,81 @@
 	if(M.mind?.assigned_role != "Clown")
 		REMOVE_TRAIT(M, TRAIT_COMIC_SANS, id)
 		M.RemoveElement(/datum/element/waddling)
+		M.DeleteComponent(/datum/component/squeak)
 
-	M.DeleteComponent(/datum/component/squeak)
+/datum/reagent/mimestrogen
+	name = "Mimestrogen"
+	id = "mimestrogen"
+	description = "Mimestrogen is an odd chemical compound that induces a variety of annoying side-effects in the average person. It also causes mild intoxication, and is toxic to clowns."
+	color = "#353535" // Should be dark grey, there are already a fair number of white chemicals
+	process_flags = ORGANIC | SYNTHETIC
+	drink_desc = "The color of the glass' surroundings seem to drain as you look at it."
+	taste_description = "an entertaining flavour"
+
+/datum/reagent/mimestrogen/on_new()
+	..()
+	var/mob/living/carbon/C = holder.my_atom
+	if(!istype(C))
+		return
+	if(C.mind)
+		if(C.mind.assigned_role == "Mime")
+			to_chat(C, "<span class='notice'>Whatever that was, it feels great!</span>")
+		else if(C.mind.assigned_role == "Clown")
+			to_chat(C, "<span class='warning'>You feel nauseous.</span>")
+			C.AdjustDizzy(volume STATUS_EFFECT_CONSTANT)
+			C.mind.miming = TRUE
+			ADD_TRAIT(C, TRAIT_COLORBLIND, id)
+		else
+			to_chat(C, "<span class='warning'>Something doesn't feel right...</span>")
+			C.AdjustDizzy(volume STATUS_EFFECT_CONSTANT)
+			C.mind.miming = TRUE // Jestosterone gives comic sans which makes one more clown-like, comic sans also unlocks clown healing, minus Jestoserone. So, mind.miming makes one more like a mime and unlocks mime healing, minus Mimestrogen.
+			ADD_TRAIT(C, TRAIT_COLORBLIND, id)
+
+/datum/reagent/mimestrogen/on_mob_life(mob/living/carbon/human/M)
+	var/update_flags = STATUS_UPDATE_NONE
+	if(prob(10))
+		M.emote("giggle")
+	if(!M.mind)
+		return ..() | update_flags
+	if(M.mind.assigned_role == "Mime")
+		update_flags |= M.adjustBruteLoss(-1.5 * REAGENTS_EFFECT_MULTIPLIER, robotic = TRUE)
+	else
+		M.AdjustDizzy(20 SECONDS, 0, 100 SECONDS)
+		if(M.client)
+			M.client.color = MATRIX_GREYSCALE
+			M.update_client_colour() // TRAIT_COLORBLIND only makes you colourblind for the wires, this fully makes it greyscale
+		if(prob(10))
+			M.EyeBlurry(10 SECONDS)
+		if(prob(6))
+			var/static/list/mime_message = list("You feel light-headed.",
+				"You can't see straight.",
+				"You feel about as entertaining as the station mime.",
+				"Muted colors and berets cloud your vision.",
+				"Your voice box feels numb.",
+				"What was that?!",
+				"You can hear silence in the distance, somehow.",
+				"You feel like miming.",
+				"Silence permeates your ears.",
+				"...",
+				"You feel like miming a performance.")
+			to_chat(M, "<span class='warning'>[pick(mime_message)]</span>")
+		if(M.mind.assigned_role == "Clown")
+			if(M.dna.species.tox_mod <= 0) // If they can't take tox damage, make them take burn damage
+				update_flags |= M.adjustFireLoss(1.5 * REAGENTS_EFFECT_MULTIPLIER, robotic = TRUE)
+			else
+				update_flags |= M.adjustToxLoss(1.5 * REAGENTS_EFFECT_MULTIPLIER)
+	return ..() | update_flags
+
+/datum/reagent/mimestrogen/on_mob_delete(mob/living/M)
+	..()
+	if(M.mind?.assigned_role != "Mime")
+		M.mind.miming = FALSE
+		if(M.client)
+			M.client.color = null
+			REMOVE_TRAIT(M, TRAIT_COLORBLIND, id)
+			M.update_client_colour() // You get stuck with permanent greyscale if it's not separated from client.color by at least one line
+		else
+			REMOVE_TRAIT(M, TRAIT_COLORBLIND, id)
 
 /datum/reagent/royal_bee_jelly
 	name = "Royal bee jelly"
diff --git a/code/modules/reagents/chemistry/recipes/others.dm b/code/modules/reagents/chemistry/recipes/others.dm
index 50c817a6d89..1ef49b5c1ed 100644
--- a/code/modules/reagents/chemistry/recipes/others.dm
+++ b/code/modules/reagents/chemistry/recipes/others.dm
@@ -289,6 +289,15 @@
 /datum/chemical_reaction/jestosterone/on_reaction(datum/reagents/holder, created_volume)
 	playsound(get_turf(holder.my_atom), 'sound/items/bikehorn.ogg', 50, 1)
 
+/datum/chemical_reaction/mimestrogen
+	name = "Mimestrogen"
+	id = "mimestrogen"
+	result = "mimestrogen"
+	required_reagents = list("blood" = 1, "sodiumchloride" = 1, "nothing" = 1, "capulettium_plus" = 1) // Or one freshly-squeezed mime
+	min_temp = T0C + 100
+	result_amount = 5
+	mix_message = "The mixture seems to drain of color before stopping at a dark grey."
+
 /datum/chemical_reaction/royal_bee_jelly
 	name = "royal bee jelly"
 	id = "royal_bee_jelly"