Adds Destroys.

code/modules/reagents/Chemistry-Holder.dm

@@ -649,6 +649,15 @@ datum
 
 				return trans_data
 
+datum/reagents/Destroy()
+	..()
+	for(var/datum/reagent/R in reagent_list)
+		qdel(R)
+	reagent_list.Cut()
+	reagent_list = null
+	if(my_atom && my_atom.reagents == src)
+		my_atom.reagents = null
+
 ///////////////////////////////////////////////////////////////////////////////////
 
 

code/modules/reagents/Chemistry-Reagents.dm

@@ -162,7 +162,7 @@ datum
 
 /* Must check the transfering of reagents and their data first. They all can point to one disease datum.
 
-			Del()
+			Destroy()
 				if(src.data["virus"])
 					var/datum/disease/D = src.data["virus"]
 					D.cure(0)
@@ -1790,7 +1790,7 @@ datum
 				..()
 				return
 
-			Del()
+			Destroy()
 				if(holder && ismob(holder.my_atom))
 					var/mob/M = holder.my_atom
 					M.status_flags &= ~FAKEDEATH
@@ -4428,5 +4428,9 @@ datum
 				..()
 				return
 
+datum/reagent/Destroy() // This should only be called by the holder, so it's already handled clearing its references
+	..()
+	holder = null
+
 // Undefine the alias for REAGENTS_EFFECT_MULTIPLER
 #undef REM