diff --git a/code/modules/mob/_modifiers/modifiers.dm b/code/modules/mob/_modifiers/modifiers.dm
index 115acb1b3e9..6e738094a12 100644
--- a/code/modules/mob/_modifiers/modifiers.dm
+++ b/code/modules/mob/_modifiers/modifiers.dm
@@ -45,6 +45,8 @@
 	var/icon_scale_percent				// Makes the holder's icon get scaled up or down.
 	var/attack_speed_percent			// Makes the holder's 'attack speed' (click delay) shorter or longer.
 	var/pain_immunity					// Makes the holder not care about pain while this is on. Only really useful to human mobs.
+	var/pulse_modifier					// Modifier for pulse, will be rounded on application, then added to the normal 'pulse' multiplier which ranges between 0 and 5 normally. Only applied if they're living.
+	var/pulse_set_level					// Positive number. If this is non-null, it will hard-set the pulse level to this. Pulse ranges from 0 to 5 normally.
 
 /datum/modifier/New(var/new_holder, var/new_origin)
 	holder = new_holder
diff --git a/code/modules/mob/_modifiers/modifiers_misc.dm b/code/modules/mob/_modifiers/modifiers_misc.dm
index fc714f30f81..42dd125d8b5 100644
--- a/code/modules/mob/_modifiers/modifiers_misc.dm
+++ b/code/modules/mob/_modifiers/modifiers_misc.dm
@@ -268,3 +268,17 @@ the artifact triggers the rage.
 	if(L.get_poison_protection() >= 1)
 		return FALSE
 	return TRUE
+<<<<<<< HEAD
+=======
+
+// Pulse modifier.
+/datum/modifier/false_pulse
+	name = "false pulse"
+	desc = "Your blood flows, despite all other factors."
+
+	on_created_text = "<span class='notice'>You feel alive.</span>"
+	on_expired_text = "<span class='notice'>You feel.. different.</span>"
+	stacks = MODIFIER_STACK_EXTEND
+
+	pulse_set_level = PULSE_NORM
+>>>>>>> 3661d6f... Merge pull request #6081 from Mechoid/PulseBasedReagentProcessing
diff --git a/code/modules/mob/living/carbon/human/life.dm b/code/modules/mob/living/carbon/human/life.dm
index 6b15fc069ee..32cc8939bc3 100644
--- a/code/modules/mob/living/carbon/human/life.dm
+++ b/code/modules/mob/living/carbon/human/life.dm
@@ -1550,20 +1550,67 @@
 /mob/living/carbon/human/proc/handle_pulse()
 	if(life_tick % 5) return pulse	//update pulse every 5 life ticks (~1 tick/sec, depending on server load)
 
-	if(!internal_organs_by_name[O_HEART])
-		return PULSE_NONE //No blood, no pulse.
-
-	if(stat == DEAD)
-		return PULSE_NONE	//that's it, you're dead, nothing can influence your pulse
-
 	var/temp = PULSE_NORM
 
+	var/modifier_shift = 0
+	var/modifier_set
+
+	if(modifiers && modifiers.len)
+		for(var/datum/modifier/mod in modifiers)
+			if(isnull(modifier_set) && !isnull(mod.pulse_set_level))
+				modifier_set = round(mod.pulse_set_level)	// Should be a whole number, but let's not take chances.
+			else if(mod.pulse_set_level > modifier_set)
+				modifier_set = round(mod.pulse_set_level)
+
+			modifier_set = max(0, modifier_set)	// No setting to negatives.
+
+			if(mod.pulse_modifier)
+				modifier_shift += mod.pulse_modifier
+
+	modifier_shift = round(modifier_shift)
+
+	if(!internal_organs_by_name[O_HEART])
+		temp = PULSE_NONE
+		if(!isnull(modifier_set))
+			temp = modifier_set
+		return temp //No blood, no pulse.
+
+	if(stat == DEAD)
+		temp = PULSE_NONE
+		if(!isnull(modifier_set))
+			temp = modifier_set
+		return temp	//that's it, you're dead, nothing can influence your pulse, aside from outside means.
+
+	var/obj/item/organ/internal/heart/Pump = internal_organs_by_name[O_HEART]
+
+	if(Pump)
+		temp += Pump.standard_pulse_level - PULSE_NORM
+
 	if(round(vessel.get_reagent_amount("blood")) <= BLOOD_VOLUME_BAD)	//how much blood do we have
-		temp = PULSE_THREADY	//not enough :(
+		temp = temp + 3	//not enough :(
 
 	if(status_flags & FAKEDEATH)
 		temp = PULSE_NONE		//pretend that we're dead. unlike actual death, can be inflienced by meds
 
+	if(!isnull(modifier_set))
+		temp = modifier_set
+
+	temp = max(0, temp + modifier_shift)	// No negative pulses.
+
+	if(Pump)
+		for(var/datum/reagent/R in reagents.reagent_list)
+			if(R.id in bradycardics)
+				if(temp <= Pump.standard_pulse_level + 3 && temp >= Pump.standard_pulse_level)
+					temp--
+			if(R.id in tachycardics)
+				if(temp <= Pump.standard_pulse_level + 1 && temp >= PULSE_NONE)
+					temp++
+			if(R.id in heartstopper) //To avoid using fakedeath
+				temp = PULSE_NONE
+			if(R.id in cheartstopper) //Conditional heart-stoppage
+				if(R.volume >= R.overdose)
+					temp = PULSE_NONE
+		return temp
 	//handles different chems' influence on pulse
 	for(var/datum/reagent/R in reagents.reagent_list)
 		if(R.id in bradycardics)
diff --git a/code/modules/organs/internal/heart.dm b/code/modules/organs/internal/heart.dm
index 10fdcada69c..b65b3bc7098 100644
--- a/code/modules/organs/internal/heart.dm
+++ b/code/modules/organs/internal/heart.dm
@@ -7,6 +7,8 @@
 	parent_organ = BP_TORSO
 	dead_icon = "heart-off"
 
+	var/standard_pulse_level = PULSE_NORM	// We run on a normal clock. This is NOT CONNECTED to species heart-rate modifier.
+
 
 /obj/item/organ/internal/heart/handle_germ_effects()
 	. = ..() //Up should return an infection level as an integer
diff --git a/code/modules/reagents/Chemistry-Reagents.dm b/code/modules/reagents/Chemistry-Reagents.dm
index 21775ea17ef..8ad8b6486d6 100644
--- a/code/modules/reagents/Chemistry-Reagents.dm
+++ b/code/modules/reagents/Chemistry-Reagents.dm
@@ -12,6 +12,7 @@
 	var/list/data = null
 	var/volume = 0
 	var/metabolism = REM // This would be 0.2 normally
+	var/list/filtered_organs = list()	// Organs that will slow the processing of this chemical.
 	var/mrate_static = FALSE	//If the reagent should always process at the same speed, regardless of species, make this TRUE
 	var/ingest_met = 0
 	var/touch_met = 0
@@ -69,6 +70,22 @@
 		// Metabolism
 		removed *= active_metab.metabolism_speed
 
+		if(ishuman(M))
+			var/mob/living/carbon/human/H = M
+			if(H.species.has_organ[O_HEART])
+				var/obj/item/organ/internal/heart/Pump = H.internal_organs_by_name[O_HEART]
+				if(!Pump)
+					removed *= 0.1
+				else if(Pump.standard_pulse_level == PULSE_NONE)	// No pulse normally means chemicals process a little bit slower than normal.
+					removed *= 0.8
+				else	// Otherwise, chemicals process as per percentage of your current pulse, or, if you have no pulse but are alive, by a miniscule amount.
+					removed *= max(0.1, H.pulse / Pump.standard_pulse_level)
+			if(filtered_organs && filtered_organs.len)
+				for(var/organ_tag in filtered_organs)
+					var/obj/item/organ/internal/O = H.internal_organs_by_name[organ_tag]
+					if(O && !O.is_broken() && prob(max(0, O.max_damage - O.damage)))
+						removed *= 0.8
+
 	if(ingest_met && (active_metab.metabolism_class == CHEM_INGEST))
 		removed = ingest_met
 	if(touch_met && (active_metab.metabolism_class == CHEM_TOUCH))
diff --git a/code/modules/reagents/Chemistry-Reagents/Chemistry-Reagents-Toxins.dm b/code/modules/reagents/Chemistry-Reagents/Chemistry-Reagents-Toxins.dm
index 6595343169e..59716a5493f 100644
--- a/code/modules/reagents/Chemistry-Reagents/Chemistry-Reagents-Toxins.dm
+++ b/code/modules/reagents/Chemistry-Reagents/Chemistry-Reagents-Toxins.dm
@@ -9,6 +9,7 @@
 	reagent_state = LIQUID
 	color = "#CF3600"
 	metabolism = REM * 0.25 // 0.05 by default. Hopefully enough to get some help, or die horribly, whatever floats your boat
+	filtered_organs = list(O_LIVER, O_KIDNEYS)
 	var/strength = 4 // How much damage it deals per unit
 
 /datum/reagent/toxin/affect_blood(var/mob/living/carbon/M, var/alien, var/removed)
@@ -253,6 +254,7 @@
 	color = "#669900"
 	metabolism = REM
 	strength = 3
+	mrate_static = TRUE
 
 /datum/reagent/toxin/zombiepowder/affect_blood(var/mob/living/carbon/M, var/alien, var/removed)
 	..()
diff --git a/html/changelogs/Mechoid - OrgansAndChems.yml b/html/changelogs/Mechoid - OrgansAndChems.yml
new file mode 100644
index 00000000000..0cc59e11f18
--- /dev/null
+++ b/html/changelogs/Mechoid - OrgansAndChems.yml	
@@ -0,0 +1,39 @@
+################################
+# Example Changelog File
+#
+# Note: This file, and files beginning with ".", and files that don't end in ".yml" will not be read. If you change this file, you will look really dumb.
+#
+# Your changelog will be merged with a master changelog. (New stuff added only, and only on the date entry for the day it was merged.)
+# When it is, any changes listed below will disappear.
+#
+# Valid Prefixes: 
+#   bugfix
+#   wip (For works in progress)
+#   tweak
+#   soundadd
+#   sounddel
+#   rscadd (general adding of nice things)
+#   rscdel (general deleting of nice things)
+#   imageadd
+#   imagedel
+#   maptweak
+#   spellcheck (typo fixes)
+#   experiment
+#################################
+
+# Your name.  
+author: Mechoid
+
+# Optional: Remove this file after generating master changelog.  Useful for PR changelogs that won't get used again.
+delete-after: True
+
+# Any changes you've made.  See valid prefix list above.
+# INDENT WITH TWO SPACES.  NOT TABS.  SPACES.
+# SCREW THIS UP AND IT WON'T WORK.
+# Also, all entries are changed into a single [] after a master changelog generation. Just remove the brackets when you add new entries.
+# Please surround your changes in  double quotes ("), as certain characters otherwise screws up compiling. The quotes will not show up in the changelog.
+changes: 
+  - rscadd: "Reagents can now have a list of organs specified to slow their processing."
+  - rscadd: "Reagents now process in the bloodstream at a rate determined by current pulse. No pulse, for any reason, will cause slightly slower processing if your species has a heart."
+  - rscadd: "The heart organ determines the 'standard pulse' if the species has one."
+  - rscadd: "Modifiers can set pulse directly, or shift it."