diff --git a/code/game/gamemodes/cult/construct_spells.dm b/code/game/gamemodes/cult/construct_spells.dm
index 62cdd5bf48..6273273c98 100644
--- a/code/game/gamemodes/cult/construct_spells.dm
+++ b/code/game/gamemodes/cult/construct_spells.dm
@@ -472,7 +472,7 @@
 		var/mob/living/carbon/human/H = owner
 		if(!H.should_have_organ(O_HEART))
 			return 1
-		if(H.vessel.remove_reagent("blood", amount))
+		if(H.remove_blood(amount))
 			return 1
 	return 0
 
@@ -673,4 +673,4 @@
 		else
 			user.visible_message("<b>\The [user]</b> lowers its fist.")
 			return
-	qdel(src)
\ No newline at end of file
+	qdel(src)
diff --git a/code/modules/mob/living/carbon/human/human.dm b/code/modules/mob/living/carbon/human/human.dm
index 990b6b4c3f..092185ed88 100644
--- a/code/modules/mob/living/carbon/human/human.dm
+++ b/code/modules/mob/living/carbon/human/human.dm
@@ -1263,7 +1263,7 @@
 			vessel.maximum_volume = species.blood_volume
 			vessel.add_reagent("blood", species.blood_volume - vessel.total_volume)
 		else if(vessel.total_volume > species.blood_volume)
-			vessel.remove_reagent("blood", vessel.total_volume - species.blood_volume)
+			vessel.remove_reagent("blood",vessel.total_volume - species.blood_volume) //This one should stay remove_reagent to work even lack of a O_heart
 			vessel.maximum_volume = species.blood_volume
 		fixblood()
 		species.update_attack_types() //VOREStation Edit - Required for any trait that updates unarmed_types in setup.
@@ -1733,7 +1733,7 @@
 			if(blood_volume < species?.blood_volume*species?.blood_level_fatal)
 				bloodtrail = 0	//Most of it's gone already, just leave it be
 			else
-				vessel.remove_reagent("blood", 1)
+				remove_blood(1)
 		if(bloodtrail)
 			if(istype(loc, /turf/simulated))
 				var/turf/T = loc
diff --git a/code/modules/mob/living/simple_mob/subtypes/animal/sif/leech.dm b/code/modules/mob/living/simple_mob/subtypes/animal/sif/leech.dm
index d206cb5820..0b1c99d64b 100644
--- a/code/modules/mob/living/simple_mob/subtypes/animal/sif/leech.dm
+++ b/code/modules/mob/living/simple_mob/subtypes/animal/sif/leech.dm
@@ -183,7 +183,7 @@
 
 		if(!docile && ishuman(host) && chemicals < max_chemicals)
 			var/mob/living/carbon/human/H = host
-			H.vessel.remove_reagent("blood", 1)
+			H.remove_blood(1)
 			if(!H.reagents.has_reagent("inaprovaline"))
 				H.reagents.add_reagent("inaprovaline", 1)
 			chemicals += 2
diff --git a/code/modules/organs/blood.dm b/code/modules/organs/blood.dm
index 071bb05e91..9d36c005d0 100644
--- a/code/modules/organs/blood.dm
+++ b/code/modules/organs/blood.dm
@@ -1,3 +1,4 @@
+#define BLOOD_MINIMUM_STOP_PROCESS 2.1 // Define to avoid hitting 0 blood.
 /****************************************************
 				BLOOD SYSTEM
 ****************************************************/
@@ -14,8 +15,12 @@ var/const/CE_STABLE_THRESHOLD = 0.5
 /mob/living/carbon/human/var/datum/reagents/vessel // Container for blood and BLOOD ONLY. Do not transfer other chems here.
 /mob/living/carbon/human/var/var/pale = 0          // Should affect how mob sprite is drawn, but currently doesn't.
 
-//Initializes blood vessels
-/mob/living/carbon/human/proc/make_blood()
+/***Initializes blood vessels
+ * Called code/modules/mob/living/carbon/human/human.dm#L1259 set_species procedure with 0 args
+ * Also called by inject_blood as fallback with amt = injected_amount
+ * MUST be followed by calling fixblood() allways.
+***/
+/mob/living/carbon/human/proc/make_blood(var/amt = 0)
 
 	if(vessel)
 		return
@@ -29,7 +34,11 @@ var/const/CE_STABLE_THRESHOLD = 0.5
 	if(!should_have_organ(O_HEART)) //We want the var for safety but we can do without the actual blood.
 		return
 
-	vessel.add_reagent("blood",species.blood_volume)
+	if(!amt)
+		vessel.add_reagent("blood",species.blood_volume)
+	else
+		vessel.add_reagent("blood", clamp(amt, 1, species.blood_volume))
+
 
 //Resets blood data
 /mob/living/carbon/human/proc/fixblood()
@@ -210,10 +219,14 @@ var/const/CE_STABLE_THRESHOLD = 0.5
 	if(!amt)
 		return 0
 
-	if(amt > vessel.get_reagent_amount("blood"))
-		amt = vessel.get_reagent_amount("blood") - 1	// Bit of a safety net; it's impossible to add blood if there's not blood already in the vessel.
+	var/current_blood = vessel.get_reagent_amount("blood")
+	if(current_blood < BLOOD_MINIMUM_STOP_PROCESS)
+		return 0 //We stop processing under 3 units of blood because apparently weird shit can make it overflowrandomly.
 
-	return vessel.remove_reagent("blood",amt * (src.mob_size/MOB_MEDIUM))
+	if(amt > current_blood)
+		amt = current_blood - 2	// Bit of a safety net; it's impossible to add blood if there's not blood already in the vessel.
+
+	return vessel.remove_reagent("blood",amt)
 
 /****************************************************
 				BLOOD TRANSFERS
@@ -256,11 +269,11 @@ var/const/CE_STABLE_THRESHOLD = 0.5
 	if(!should_have_organ(O_HEART))
 		return null
 
-	if(vessel.get_reagent_amount("blood") < amount)
+	if(vessel.get_reagent_amount("blood") < max(amount, BLOOD_MINIMUM_STOP_PROCESS))
 		return null
 
 	. = ..()
-	vessel.remove_reagent("blood",amount) // Removes blood if human
+	remove_blood(amount) // Removes blood if human
 
 //Transfers blood from container ot vessels
 /mob/living/carbon/proc/inject_blood(var/datum/reagent/blood/injected, var/amount)
@@ -288,8 +301,28 @@ var/const/CE_STABLE_THRESHOLD = 0.5
 
 	var/datum/reagent/blood/our = get_blood(vessel)
 
-	if (!injected || !our)
+	if (!injected)
 		return
+	if(!our)
+		log_debug("[src] has no blood reagent, proceeding with fallback reinitialization.")
+		var/vessel_old = vessel
+		vessel = null
+		qdel(vessel_old)
+		make_blood(amount)
+		if(!vessel)
+			log_debug("Failed to re-initialize blood datums on [src]!")
+			return
+		if(vessel.total_volume < species.blood_volume)
+			vessel.add_reagent("blood", species.blood_volume - vessel.total_volume)
+		else if(vessel.total_volume > species.blood_volume)
+			vessel.maximum_volume = species.blood_volume
+		fixblood()
+		our = get_blood(vessel)
+		if(!our)
+			log_debug("Failed to re-initialize blood datums on [src]!")
+			return
+
+
 	if(blood_incompatible(injected.data["blood_type"],our.data["blood_type"],injected.data["species"],our.data["species"]) )
 		reagents.add_reagent("toxin",amount * 0.5)
 		reagents.update_total()
diff --git a/code/modules/organs/organ_external.dm b/code/modules/organs/organ_external.dm
index 0c85e2aa27..b22ee48e98 100644
--- a/code/modules/organs/organ_external.dm
+++ b/code/modules/organs/organ_external.dm
@@ -750,7 +750,7 @@ Note that amputating the affected organ does in fact remove the infection from t
 			if(!(W.can_autoheal() || (bicardose && inaprovaline) || myeldose))	//bicaridine and inaprovaline stop internal wounds from growing bigger with time, unless it is so small that it is already healing
 				W.open_wound(0.1 * wound_update_accuracy)
 
-			owner.vessel.remove_reagent("blood", wound_update_accuracy * W.damage/40) //line should possibly be moved to handle_blood, so all the bleeding stuff is in one place.
+			owner.remove_blood( wound_update_accuracy * W.damage/40) //line should possibly be moved to handle_blood, so all the bleeding stuff is in one place.
 			if(prob(1 * wound_update_accuracy))
 				owner.custom_pain("You feel a stabbing pain in your [name]!", 50)
 
diff --git a/code/modules/xenoarcheaology/effects/vampire.dm b/code/modules/xenoarcheaology/effects/vampire.dm
index 29cabc5b2a..757f02889a 100644
--- a/code/modules/xenoarcheaology/effects/vampire.dm
+++ b/code/modules/xenoarcheaology/effects/vampire.dm
@@ -27,7 +27,7 @@
 		B.target_turf = pick(RANGE_TURFS(1, holder))
 		B.blood_DNA = list()
 		B.blood_DNA[M.dna.unique_enzymes] = M.dna.b_type
-		M.vessel.remove_reagent("blood",rand(10,30))
+		M.remove_blood(rand(10,30))
 
 /datum/artifact_effect/vampire/DoEffectTouch(var/mob/user)
 	bloodcall(user)
diff --git a/code/modules/xenoarcheaology/finds/special.dm b/code/modules/xenoarcheaology/finds/special.dm
index e7c66148d5..af22d90dbf 100644
--- a/code/modules/xenoarcheaology/finds/special.dm
+++ b/code/modules/xenoarcheaology/finds/special.dm
@@ -134,7 +134,7 @@
 		B.target_turf = pick(range(1, src))
 		B.blood_DNA = list()
 		B.blood_DNA[M.dna.unique_enzymes] = M.dna.b_type
-		M.vessel.remove_reagent("blood",rand(25,50))
+		M.remove_blood(rand(25,50))
 
 //animated blood 2 SPOOKY
 /obj/effect/decal/cleanable/blood/splatter/animated