diff --git a/code/__DEFINES/reagents.dm b/code/__DEFINES/reagents.dm
index 44e97ef345..8864e41ae9 100644
--- a/code/__DEFINES/reagents.dm
+++ b/code/__DEFINES/reagents.dm
@@ -76,3 +76,8 @@
 //Chemical reaction flags, for determining reaction specialties
 #define REACTION_CLEAR_IMPURE       (1<<0)  //Convert into impure/pure on reaction completion
 #define REACTION_CLEAR_INVERSE      (1<<1)  //Convert into inverse on reaction completion when purity is low enough
+
+//Chemical blacklists for smartdarts
+GLOBAL_LIST_INIT(blacklisted_medchems, list(
+	/datum/reagent/medicine/morphine, /datum/reagent/medicine/haloperidol,	//harmful chemicals in medicine
+	))
diff --git a/code/modules/projectiles/projectile/bullets/dart_syringe.dm b/code/modules/projectiles/projectile/bullets/dart_syringe.dm
index bc2a7c40fb..318acb66b5 100644
--- a/code/modules/projectiles/projectile/bullets/dart_syringe.dm
+++ b/code/modules/projectiles/projectile/bullets/dart_syringe.dm
@@ -60,6 +60,8 @@
 			if(M.can_inject(null, FALSE, def_zone, piercing)) // Pass the hit zone to see if it can inject by whether it hit the head or the body.
 				..(target, blocked, TRUE)
 				for(var/datum/reagent/medicine/R in reagents.reagent_list) //OD prevention time!
+					if(R.type in GLOB.blacklisted_medchems)
+						continue
 					if(M.reagents.has_reagent(R.type))
 						if(R.overdose_threshold == 0 || emptrig == TRUE) //Is there a possible OD?
 							M.reagents.add_reagent(R.type, R.volume)